Table 1. Summary of Biological... | American Society of Hematology

Table 1.

Summary of Biological Properties of STAT5A Mutants

STAT5A Mutant	293T Cells					32D Cells
STAT5A Mutant	Tyrosine PO₄	Dimerization^*	DNA Binding	Transactivation	DN Activity^†	Inhibition of IL-3–Dependent Proliferation	Inhibition of Neutrophil Maturation
STAT5A WT	++	++	++	++	−	−	−
STAT5A/WKR	+	−	−	−	++	+	++
STAT5A/RQQ	++	++	++	++	−
STAT5A/EE	++	++	−	++	−
STAT5A/VVV	+	+	−	−	+
STAT5A/Δ53C	++	++	+++	+/−	++	+	++

STAT5A Mutant	293T Cells					32D Cells
STAT5A Mutant	Tyrosine PO₄	Dimerization^*	DNA Binding	Transactivation	DN Activity^†	Inhibition of IL-3–Dependent Proliferation	Inhibition of Neutrophil Maturation
STAT5A WT	++	++	++	++	−	−	−
STAT5A/WKR	+	−	−	−	++	+	++
STAT5A/RQQ	++	++	++	++	−
STAT5A/EE	++	++	−	++	−
STAT5A/VVV	+	+	−	−	+
STAT5A/Δ53C	++	++	+++	+/−	++	+	++

JAK2-dependent heterodimerization with STAT5B.

Inhibition of erythropoietin-induced STAT5-dependent luciferase induction.