Patients’ Characteristics According to Status at Transplant
| Characteristics . | Poor Risk (N = 36) (≥3 CR, relapse and refractory) . | Good Risk (N = 66) (1 CR and 2 CR) . | P* . |
|---|---|---|---|
| Median age (yr) (range) | 6.3 (0.3-14) | 5.0 (0.5-15) | .08 |
| Median weight (kg) (range) | 21 (4.4-83) | 19 (6.5-67) | .16 |
| <20/≥20 | 14/22 | 35/31 | |
| Gender (male/female) | 23/13 | 35/31 | .30 |
| Type of donor | |||
| Related | 18 | 24 | .21 |
| Unrelated | 18 | 42 | .38 |
| ALL/AML | 27/9† | 43/23‡ | |
| Disease status at transplant | |||
| First CR | — | 18 | <.001 |
| Second CR | — | 48 | |
| ≥Third CR | 15 | — | |
| First relapse | 4 | — | |
| Second relapse | 10 | — | |
| Partial response | 3 | — | |
| Refractory to chemotherapy | 4 | ||
| Cytogenetics | .65 | ||
| Unfavorable | 8 | 20 | |
| Intermediate1-153 | 23 | 39 | |
| Favorable | 5 | 7 | |
| First relapse | |||
| On therapy | 20 | 27 | .65 |
| Off therapy | 12 | 21 | |
| Median d from diagnosis to first relapse | 506 (105-1,631) | 472 (42-1,725) | .80 |
| Median d from last CR to transplant1-155 | 62 (0-366) | 93 (18-442) | .08 |
| Previous autologous/allogeneic transplants | 11/2 | 5 | <.001 |
| Characteristics . | Poor Risk (N = 36) (≥3 CR, relapse and refractory) . | Good Risk (N = 66) (1 CR and 2 CR) . | P* . |
|---|---|---|---|
| Median age (yr) (range) | 6.3 (0.3-14) | 5.0 (0.5-15) | .08 |
| Median weight (kg) (range) | 21 (4.4-83) | 19 (6.5-67) | .16 |
| <20/≥20 | 14/22 | 35/31 | |
| Gender (male/female) | 23/13 | 35/31 | .30 |
| Type of donor | |||
| Related | 18 | 24 | .21 |
| Unrelated | 18 | 42 | .38 |
| ALL/AML | 27/9† | 43/23‡ | |
| Disease status at transplant | |||
| First CR | — | 18 | <.001 |
| Second CR | — | 48 | |
| ≥Third CR | 15 | — | |
| First relapse | 4 | — | |
| Second relapse | 10 | — | |
| Partial response | 3 | — | |
| Refractory to chemotherapy | 4 | ||
| Cytogenetics | .65 | ||
| Unfavorable | 8 | 20 | |
| Intermediate1-153 | 23 | 39 | |
| Favorable | 5 | 7 | |
| First relapse | |||
| On therapy | 20 | 27 | .65 |
| Off therapy | 12 | 21 | |
| Median d from diagnosis to first relapse | 506 (105-1,631) | 472 (42-1,725) | .80 |
| Median d from last CR to transplant1-155 | 62 (0-366) | 93 (18-442) | .08 |
| Previous autologous/allogeneic transplants | 11/2 | 5 | <.001 |
Fisher’s test was used for categorical variables and Kruskal-Wallis Test for noncategorical variables.
One patient with AML associated to Down syndrome.
One patient with AML associated to Down Syndrome and another with congenital AML.
Including normal and not available cytogenetics.
Only for patients in CR at time of transplant.