Table 1.

Pretreatment Patient Characteristics

Patient No. Age/Sex (yrs) Pretreatment Disease Duration (mos) Pathologic Diagnosis16Prior Therapy Stage at Start of Cladribine Sites of Disease Involvement
1  33/F  204 Presumptive  Prednisone, vinblastine, azathioprine, VP-16, methotrexate Radiation  I  Skin, external auditory canals, mouth, vagina, diabetes insipidus  
2  57/M 7  Definitive  Prednisone  II  Skin, neutropenia 
3  20/M  176  Presumptive  Prednisone, vinblastine, suppressin A (experimental), VP-16 C5 vertebrectomy I  Bone (vertebrae, orbits, skull, sternum, ribs and pelvis)  
4  50/M  21  Presumptive Prednisone Radiation Surgical debridement  I  Bone (mandible and ribs), gingiva, tooth loss, lung  
5  42/F  133  Diagnosis  Prednisone, vinblastine Radiation Bowel resection, partial hepatic resection  I  Skin, mouth, vagina, colon, diabetes insipidus  
6  35/M  99  Diagnosis Topical nitrogen, mustard, VP-16 Electron beam radiation  I  Skin, soft tissue, diabetes Insipidus, pulmonary  
7  72/M  34  Definitive  Prednisone, cyclophosphamide Radiation  I  Skin  
47/M  114  Definitive  Radiation  II  Bone (mandible and maxilla), lung, edentulous  
9  37/M  22  Diagnosis Prednisone, vinblastine Radiation Pericardiectomy  III  Bone (mandible, radius and ribs), soft tissue, lung, lymphadenopathy, ascites, diabetes insipidus 
10  68/F  64  Diagnosis  Vinblastine, methotrexate, 6-thioguanine Radiation  I  Skin, mouth, vagina, anemia  
11  34/M  146  Definitive Vinblastine, vincristine, interferon, methotrexate, VP-16, prednisone Radiation  II  Bone (skull, hips, vertebrae, clavicle, tibia and ribs), lung  
12  46/F  253 Definitive  Vinblastine, methotrexate, isotretinoin, interferon Radiation  I  Skin  
13 19/F  6  Presumptive  None  II  Bone (skull, femur, fibula and pelvis), lung, lymphadenopathy 
Patient No. Age/Sex (yrs) Pretreatment Disease Duration (mos) Pathologic Diagnosis16Prior Therapy Stage at Start of Cladribine Sites of Disease Involvement
1  33/F  204 Presumptive  Prednisone, vinblastine, azathioprine, VP-16, methotrexate Radiation  I  Skin, external auditory canals, mouth, vagina, diabetes insipidus  
2  57/M 7  Definitive  Prednisone  II  Skin, neutropenia 
3  20/M  176  Presumptive  Prednisone, vinblastine, suppressin A (experimental), VP-16 C5 vertebrectomy I  Bone (vertebrae, orbits, skull, sternum, ribs and pelvis)  
4  50/M  21  Presumptive Prednisone Radiation Surgical debridement  I  Bone (mandible and ribs), gingiva, tooth loss, lung  
5  42/F  133  Diagnosis  Prednisone, vinblastine Radiation Bowel resection, partial hepatic resection  I  Skin, mouth, vagina, colon, diabetes insipidus  
6  35/M  99  Diagnosis Topical nitrogen, mustard, VP-16 Electron beam radiation  I  Skin, soft tissue, diabetes Insipidus, pulmonary  
7  72/M  34  Definitive  Prednisone, cyclophosphamide Radiation  I  Skin  
47/M  114  Definitive  Radiation  II  Bone (mandible and maxilla), lung, edentulous  
9  37/M  22  Diagnosis Prednisone, vinblastine Radiation Pericardiectomy  III  Bone (mandible, radius and ribs), soft tissue, lung, lymphadenopathy, ascites, diabetes insipidus 
10  68/F  64  Diagnosis  Vinblastine, methotrexate, 6-thioguanine Radiation  I  Skin, mouth, vagina, anemia  
11  34/M  146  Definitive Vinblastine, vincristine, interferon, methotrexate, VP-16, prednisone Radiation  II  Bone (skull, hips, vertebrae, clavicle, tibia and ribs), lung  
12  46/F  253 Definitive  Vinblastine, methotrexate, isotretinoin, interferon Radiation  I  Skin  
13 19/F  6  Presumptive  None  II  Bone (skull, femur, fibula and pelvis), lung, lymphadenopathy 
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