Hypothesized Roles of Caspase-3 and Calpain in Platelet Activation Events
| Agonist-Induced Event . | Hypothesized Direct Action of . | |
|---|---|---|
| Caspase-3 . | Calpain . | |
| α-Granule release | − | − |
| Shape change | − | − |
| Aggregation | − | − |
| Activation of PS exposing enzyme | + | − |
| Termination of PS exposing system | − | + |
| Termination of Filopod extension | Not examined | + |
| Microparticle release | (+)3-150 | + |
| Moesin cleavage | (+)3-150 | (+)3-150 |
| Agonist-Induced Event . | Hypothesized Direct Action of . | |
|---|---|---|
| Caspase-3 . | Calpain . | |
| α-Granule release | − | − |
| Shape change | − | − |
| Aggregation | − | − |
| Activation of PS exposing enzyme | + | − |
| Termination of PS exposing system | − | + |
| Termination of Filopod extension | Not examined | + |
| Microparticle release | (+)3-150 | + |
| Moesin cleavage | (+)3-150 | (+)3-150 |
(+) indicates uncertain.