Lysis of Human Tumor Cell Lines by MUC1-Specific CTL
| Tumor Cell Lines* . | HLA-A2 Expression . | MUC1 Expression . | CTL.M1.1 % Specific Lysis at E:T . | CTL.M1.2 % Specific Lysis at E:T . | ||||
|---|---|---|---|---|---|---|---|---|
| 30 . | 10 . | 3 . | 30 . | 10 . | 3 . | |||
| MCF-7 | + | + | 39 | 30 | 16 | 58 | 41 | 23 |
| MZ1774-RCC | + | + | 38 | 33 | 18 | 43 | 18 | 12 |
| A-498 | + | + | 39 | 22 | 14 | 29 | 19 | 14 |
| NWI-RCC | + | + | 51 | 27 | 22 | 36 | 25 | 10 |
| HPAF | + | + | 36 | 24 | 16 | 41 | 28 | 11 |
| ACHN | − | + | 9 | 3 | 3 | 7 | 3 | 1 |
| Caki-2 | − | + | 5 | 5 | 2 | 3 | 1 | 0 |
| SK-OV-3 | − | + | 4 | 3 | 3 | 4 | 1 | 1 |
| HCT 116 | + | − | 9 | 5 | 0 | 7 | 3 | 4 |
| Croft | + | − | 9 | 3 | 3 | 13 | 10 | 5 |
| 3D7 | + | − | 8 | 4 | 0 | 7 | 6 | 1 |
| K562 | − | + | 9 | 3 | 2 | 6 | 3 | 3 |
| Tumor Cell Lines* . | HLA-A2 Expression . | MUC1 Expression . | CTL.M1.1 % Specific Lysis at E:T . | CTL.M1.2 % Specific Lysis at E:T . | ||||
|---|---|---|---|---|---|---|---|---|
| 30 . | 10 . | 3 . | 30 . | 10 . | 3 . | |||
| MCF-7 | + | + | 39 | 30 | 16 | 58 | 41 | 23 |
| MZ1774-RCC | + | + | 38 | 33 | 18 | 43 | 18 | 12 |
| A-498 | + | + | 39 | 22 | 14 | 29 | 19 | 14 |
| NWI-RCC | + | + | 51 | 27 | 22 | 36 | 25 | 10 |
| HPAF | + | + | 36 | 24 | 16 | 41 | 28 | 11 |
| ACHN | − | + | 9 | 3 | 3 | 7 | 3 | 1 |
| Caki-2 | − | + | 5 | 5 | 2 | 3 | 1 | 0 |
| SK-OV-3 | − | + | 4 | 3 | 3 | 4 | 1 | 1 |
| HCT 116 | + | − | 9 | 5 | 0 | 7 | 3 | 4 |
| Croft | + | − | 9 | 3 | 3 | 13 | 10 | 5 |
| 3D7 | + | − | 8 | 4 | 0 | 7 | 6 | 1 |
| K562 | − | + | 9 | 3 | 2 | 6 | 3 | 3 |
The cytotoxic activity of CTL.M1.1 and CTL.M1.2 against human tumor cell lines was analyzed in a standard 51Cr-release assay.