Table 4.

Effect of Jaspamide on Production of Superoxide by Monocytes and HL-60 Cells Incubated in the Absence or Presence of PMA

TreatmentO2 production (nmol) per 106 Cells During 60 min
Monocytes HL-60 Cells
−PMA +PMA −PMA +PMA
Nil  3.8 ± 0.3 38.3 ± 7.8  0  1.7 ± 0.35  
DMSO 0.01% 5.0 ± 2.0  42.3 ± 3.7  0  1.8 ± 0.05 
Jaspamide 10−7 mol/L  3.8 ± 0.1 43.1 ± 5.2  0  2.35 ± 0.4 
TreatmentO2 production (nmol) per 106 Cells During 60 min
Monocytes HL-60 Cells
−PMA +PMA −PMA +PMA
Nil  3.8 ± 0.3 38.3 ± 7.8  0  1.7 ± 0.35  
DMSO 0.01% 5.0 ± 2.0  42.3 ± 3.7  0  1.8 ± 0.05 
Jaspamide 10−7 mol/L  3.8 ± 0.1 43.1 ± 5.2  0  2.35 ± 0.4 

O2 production (nmol) per 106 cells during 60 minutes. Results expressed as mean ± SE of 3 experiments performed in quadruplicate.

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