Correlation Between ERK Activation and PAC1 Downregulation
| ERK Activation . | No. . | PAC1 Downregulation . | |
|---|---|---|---|
| Positive4-151 . | Negative . | ||
| Positive4-150 | 19 | 16 | 3 |
| Negative | 7 | 1 | 6 |
| Total | 26 | 17 | 9 |
| ERK Activation . | No. . | PAC1 Downregulation . | |
|---|---|---|---|
| Positive4-151 . | Negative . | ||
| Positive4-150 | 19 | 16 | 3 |
| Negative | 7 | 1 | 6 |
| Total | 26 | 17 | 9 |
P = .002.
Defined as positive when the value of the ERK2 phosphorylation divided by the α-tubulin expression was greater than one third the value of K562 cell by immunoblot analysis.
Defined as positive when the value of the PAC1 expression was less than one half the mean value of normal BM samples by semiquantitative RT-PCR.