Correlation Between ERK Activation and MEK Activation
| ERK Activation . | No. . | MEK Activation . | |
|---|---|---|---|
| Positive† . | Negative . | ||
| Positive* | 19 | 14 | 5 |
| Negative | 7 | 7 | 0 |
| Total | 26 | 21 | 5 |
| ERK Activation . | No. . | MEK Activation . | |
|---|---|---|---|
| Positive† . | Negative . | ||
| Positive* | 19 | 14 | 5 |
| Negative | 7 | 7 | 0 |
| Total | 26 | 21 | 5 |
P = .28.
Defined as positive when the value of the ERK2 phosphorylation divided by the α-tubulin expression was greater than one third the value of K562 cell by immunoblot analysis.
Defined as positive when the value of the MEK phosphorylation divided by the α-tubulin expression was greater than twofold the mean value of normal BM samples by immunoblot analysis.14