Nuclear Body Proteins
| Proteins . | Characteristics . |
|---|---|
| Cellular | |
| PML | RING finger-B box-coiled coil170,173,191 192 |
| Sp100 | Coiled coil—present in viral inclusions191 569 |
| NDP 52 | LIM domain protein, may not be true NB protein570 571 |
| NDP55 | Not characterized—present in viral inclusions192 |
| Int-6 | MMTV insertion site, translational elongation factor572 573 |
| PIC1/SUMO-1/Sentrin | Ubiquitin homology (UbH) domain, may play a role in protein turnover179,220 223 |
| 65 kD | Human autoantigen191 |
| HAUSP | USP family—involucrin homology574 |
| PLZF | Zinc finger transcription factor216 228 |
| ISG20 | IFN-stimulated gene product of 20 kD218 |
| P0, P1, P2 | Ribosomal proteins essential for translation230 |
| CBP | CREB binding protein—transcriptional coactivator/histone acetyl transferase202 |
| RFP | Ret finger protein (RFP) RING finger, B-box coiled coil class575 |
| Cyclin D3 | Cell cycle regulator, colocalizes with herpes virus ICP0 protein in NB during viral infection576 |
| L7 | Leucine zipper protein220 |
| HP1 | Heterochromatin-associated protein204 |
| BAX | Stimulator of apoptosis252 |
| KIP1/p27 | Cell cycle regulator252 |
| Glyceraldehyde-3-phosphatedehydrogenase (GADPH) | Possible RNA chaperone577 |
| SP 140 | Zn finger—bromodomain219 |
| Viral | |
| Herpes simplex virus | ICPO/Vm110-RING finger protein— essential for viral replication239 |
| Cytomegalovirus | El1, El 2—early immediate products243 244 |
| Human papillomavirus | L2—minor capsid protein. E2-early product, transcriptiona and replication factor245 |
| Epstein-Barr virus | EBNA5 early gene product, complexes with Rb242 |
| Arenavirus | Z protein RING finger172 |
| Adenovirus | E4 ORF3—early gene product. Coiled coil protein—essential for viral replication578 |
| E1A-E1B adenoviral early proteins238 578 |
| Proteins . | Characteristics . |
|---|---|
| Cellular | |
| PML | RING finger-B box-coiled coil170,173,191 192 |
| Sp100 | Coiled coil—present in viral inclusions191 569 |
| NDP 52 | LIM domain protein, may not be true NB protein570 571 |
| NDP55 | Not characterized—present in viral inclusions192 |
| Int-6 | MMTV insertion site, translational elongation factor572 573 |
| PIC1/SUMO-1/Sentrin | Ubiquitin homology (UbH) domain, may play a role in protein turnover179,220 223 |
| 65 kD | Human autoantigen191 |
| HAUSP | USP family—involucrin homology574 |
| PLZF | Zinc finger transcription factor216 228 |
| ISG20 | IFN-stimulated gene product of 20 kD218 |
| P0, P1, P2 | Ribosomal proteins essential for translation230 |
| CBP | CREB binding protein—transcriptional coactivator/histone acetyl transferase202 |
| RFP | Ret finger protein (RFP) RING finger, B-box coiled coil class575 |
| Cyclin D3 | Cell cycle regulator, colocalizes with herpes virus ICP0 protein in NB during viral infection576 |
| L7 | Leucine zipper protein220 |
| HP1 | Heterochromatin-associated protein204 |
| BAX | Stimulator of apoptosis252 |
| KIP1/p27 | Cell cycle regulator252 |
| Glyceraldehyde-3-phosphatedehydrogenase (GADPH) | Possible RNA chaperone577 |
| SP 140 | Zn finger—bromodomain219 |
| Viral | |
| Herpes simplex virus | ICPO/Vm110-RING finger protein— essential for viral replication239 |
| Cytomegalovirus | El1, El 2—early immediate products243 244 |
| Human papillomavirus | L2—minor capsid protein. E2-early product, transcriptiona and replication factor245 |
| Epstein-Barr virus | EBNA5 early gene product, complexes with Rb242 |
| Arenavirus | Z protein RING finger172 |
| Adenovirus | E4 ORF3—early gene product. Coiled coil protein—essential for viral replication578 |
| E1A-E1B adenoviral early proteins238 578 |