Evidence for Involvement of RAR in Myeloid Development
| Vitamin A deficiency results in abnormal hematopoiesis18 19 |
| Retinoids preferentially stimulate granulopoiesis20 21 |
| RARα is expressed preferentially in myeloid cells27-29 |
| HL60 cells undergo differentiation with ATRA via RAR/RXR heterodimer stimulation69-71 |
| Wild-type and dominant negative RARα overexpression results in a differentiation block at the promyelocyte stage82,83 85 |
| RARα targets myeloid genes, of which C/EBP-ε is a model tar- get122-125 126 (and see Table1) |
| ATRA upregulates RARα94 |
| RARα upregulates p21 and decreases cell growth130 131 |
| Cross-talk between retinoid and IFN system to induce differentiation and halt cell growth145 146 |
| Vitamin A deficiency results in abnormal hematopoiesis18 19 |
| Retinoids preferentially stimulate granulopoiesis20 21 |
| RARα is expressed preferentially in myeloid cells27-29 |
| HL60 cells undergo differentiation with ATRA via RAR/RXR heterodimer stimulation69-71 |
| Wild-type and dominant negative RARα overexpression results in a differentiation block at the promyelocyte stage82,83 85 |
| RARα targets myeloid genes, of which C/EBP-ε is a model tar- get122-125 126 (and see Table1) |
| ATRA upregulates RARα94 |
| RARα upregulates p21 and decreases cell growth130 131 |
| Cross-talk between retinoid and IFN system to induce differentiation and halt cell growth145 146 |