CD30 and OX40/CD134 Expression in T-cell Lymphomas and Other Neoplasms
| Tumor Type . | No. of Cases . | CD30 . | OX40/CD134 . | Pattern of CD30/CD134 Coexpression . |
|---|---|---|---|---|
| T-cell lymphoma | 148 | |||
| Anaplastic large cell | 47 | 46 | 8 | |
| Primary cutaneous | 8 | 8 | 2 | 2 focal |
| ALK+nodal | 20 | 20 | 2 | 1 diffuse |
| 1 focal | ||||
| ALK− nodal | 19 | 18 | 4 | 3 diffuse |
| 1 focal | ||||
| Large-cell morphology | 21 | 10 | 10 | 1 diffuse |
| 3 focal | ||||
| Mixed cell morphology | 16 | 4 | 7 | 4 focal |
| Small cell | 7 | 0 | 0 | — |
| Angioimmunoblastic | 16 | 1 | 15 | 1 focal |
| Histiocyte-rich | 7 | 1 | 6 | 1 focal |
| Angiocentric | 4 | 0 | 4 | — |
| Mycosis fungiodes (skin) | 5 | 0 | 0 | — |
| MF nodal transformation | 4 | 3 | 3 | 1 diffuse, 2 focal |
| HTLV-1–associated | 2 | 0 | 2 | — |
| T/NK (including CD8+)* | 6 | 1 | 0 | — |
| Lymphoblastic | 13 | 0 | 0 | |
| B-cell lymphoma | 20 | NT | 0 | |
| Hodgkin’s disease | ||||
| Classical-type | 20 | 20† | 17‡ | Occasional RS cells |
| Lymphocyte-predominance | 4 | 0 | 4‡ | |
| Myeloid proliferations | 5 | NT | 0 | |
| Nonhematopoietic neoplasms | ||||
| Carcinoma | 20 | NT | 0 | |
| Other1-153 | 11 | NT | 0 |
| Tumor Type . | No. of Cases . | CD30 . | OX40/CD134 . | Pattern of CD30/CD134 Coexpression . |
|---|---|---|---|---|
| T-cell lymphoma | 148 | |||
| Anaplastic large cell | 47 | 46 | 8 | |
| Primary cutaneous | 8 | 8 | 2 | 2 focal |
| ALK+nodal | 20 | 20 | 2 | 1 diffuse |
| 1 focal | ||||
| ALK− nodal | 19 | 18 | 4 | 3 diffuse |
| 1 focal | ||||
| Large-cell morphology | 21 | 10 | 10 | 1 diffuse |
| 3 focal | ||||
| Mixed cell morphology | 16 | 4 | 7 | 4 focal |
| Small cell | 7 | 0 | 0 | — |
| Angioimmunoblastic | 16 | 1 | 15 | 1 focal |
| Histiocyte-rich | 7 | 1 | 6 | 1 focal |
| Angiocentric | 4 | 0 | 4 | — |
| Mycosis fungiodes (skin) | 5 | 0 | 0 | — |
| MF nodal transformation | 4 | 3 | 3 | 1 diffuse, 2 focal |
| HTLV-1–associated | 2 | 0 | 2 | — |
| T/NK (including CD8+)* | 6 | 1 | 0 | — |
| Lymphoblastic | 13 | 0 | 0 | |
| B-cell lymphoma | 20 | NT | 0 | |
| Hodgkin’s disease | ||||
| Classical-type | 20 | 20† | 17‡ | Occasional RS cells |
| Lymphocyte-predominance | 4 | 0 | 4‡ | |
| Myeloid proliferations | 5 | NT | 0 | |
| Nonhematopoietic neoplasms | ||||
| Carcinoma | 20 | NT | 0 | |
| Other1-153 | 11 | NT | 0 |
Negative staining corresponds to reactivity in less than 5% of tumor cells.
Abbreviation: NT, not tested.
Includes CD8+ large granular lymphocytic tumors (4 cases) and natural killer leukemia/lymphoma (2).
Staining of neoplastic RS cells and variants.
Background nonneoplastic T cells; in 7 of 20 classical HD, occasional RS cells showed weak staining for OX40/CD134 as well.
Includes mesothelioma (4 cases), carcinoid, seminoma, liposarcoma, leiomyosarcoma, rhabdomyosarcoma, and 2 undifferentiated neoplasms.