Table 1. Effect of srhCD40L on... | American Society of Hematology

Table 1.

Effect of srhCD40L on Proliferation and the Induction of Apoptosis of Human Breast Carcinoma Cell Lines

Cell Line	Treatment	CPM (±SD)	NMP (U/mL)
MDA-231 (CD40⁺)	—	14,567 (216)	<2
	srhCD40L (1 μg/mL)	6,875 (158)^†	26^*
	srhCD40L (1 μg/mL)	9,778 (364)^*	18^*
	Anti-fas (10 ng/mL)	5,098 (206)^†	38^*
T47D (CD40⁺)	—	37,658 (1,897)	8
	srhCD40L (10 μg/mL)	22,592 (2,025)^*	36^*
	srhCD40L (1 μg/mL)	27,798 (2,046)^*	27^*
	Anti-fas (10 μg/mL)	11,674 (1,923)^†	58^*
MCF-7 (CD40⁻)	—	19,867 (1,216)	0
	srhCD40L (10 μg/mL)	18,976 (321)	0
	srhCD40L (1 μg/mL)	20,981 (1,786)	0
	Anti-fas (10 μg/mL)	7,930 (483)^†	37^*

Cell Line	Treatment	CPM (±SD)	NMP (U/mL)
MDA-231 (CD40⁺)	—	14,567 (216)	<2
	srhCD40L (1 μg/mL)	6,875 (158)^†	26^*
	srhCD40L (1 μg/mL)	9,778 (364)^*	18^*
	Anti-fas (10 ng/mL)	5,098 (206)^†	38^*
T47D (CD40⁺)	—	37,658 (1,897)	8
	srhCD40L (10 μg/mL)	22,592 (2,025)^*	36^*
	srhCD40L (1 μg/mL)	27,798 (2,046)^*	27^*
	Anti-fas (10 μg/mL)	11,674 (1,923)^†	58^*
MCF-7 (CD40⁻)	—	19,867 (1,216)	0
	srhCD40L (10 μg/mL)	18,976 (321)	0
	srhCD40L (1 μg/mL)	20,981 (1,786)	0
	Anti-fas (10 μg/mL)	7,930 (483)^†	37^*

Cell lines were incubated for 72 hours with either srhCD40L or anti-fas as indicated in the Methods. Proliferation was assessed by ³H-thymidine incorporation and apoptosis was by NMP levels in the supernatants.

P > .05.

†

P > .01.

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