Characteristics of E2A-HLF Leukemic Mice
| Mouse No. (sex) . | Age at Diagnosis (mo) . | Macroscopic Tumor Sites . | Hematological Examination . | Surface Marker Analysis . | DNA Status (TCR) . | ||
|---|---|---|---|---|---|---|---|
| WBC (×103/μL) . | Hb (g/dL) . | Plt (×103/μL) . | |||||
| Thy1.2 (+) | |||||||
| 1-17-9 | 5.5 | Thy, Spl, LN | 43.8 | 4.5 | 6.2 | CD4 (−) CD8 (+) | G/R |
| (M) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-2 | 6.0 | Thy, Spl, LN | 20.5 | 8.0 | 10.5 | CD4 (+) CD8 (+) | G/R |
| (F) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-8-2 | 4.2 | Thy, Spl, LN | 19.8 | 7.7 | 22.2 | CD4 (+) CD8 (−) | G/R |
| (F) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-8-4 | 5.2 | Thy, Spl, LN | 15.6 | 8.5 | 23.3 | CD4 (+) CD8 (−) | G/R |
| (F) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-10-8 | 3.1 | Thy, Spl, LN | 52.3 | 8.1 | 30.1 | CD4 (+) CD8 (−) | G/R |
| (M) | (>90% lymphoblasts) | B220 (−) | |||||
| Mouse No. (sex) . | Age at Diagnosis (mo) . | Macroscopic Tumor Sites . | Hematological Examination . | Surface Marker Analysis . | DNA Status (TCR) . | ||
|---|---|---|---|---|---|---|---|
| WBC (×103/μL) . | Hb (g/dL) . | Plt (×103/μL) . | |||||
| Thy1.2 (+) | |||||||
| 1-17-9 | 5.5 | Thy, Spl, LN | 43.8 | 4.5 | 6.2 | CD4 (−) CD8 (+) | G/R |
| (M) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-2 | 6.0 | Thy, Spl, LN | 20.5 | 8.0 | 10.5 | CD4 (+) CD8 (+) | G/R |
| (F) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-8-2 | 4.2 | Thy, Spl, LN | 19.8 | 7.7 | 22.2 | CD4 (+) CD8 (−) | G/R |
| (F) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-8-4 | 5.2 | Thy, Spl, LN | 15.6 | 8.5 | 23.3 | CD4 (+) CD8 (−) | G/R |
| (F) | (>90% lymphoblasts) | B220 (−) | |||||
| Thy1.2 (+) | |||||||
| 2-17-10-8 | 3.1 | Thy, Spl, LN | 52.3 | 8.1 | 30.1 | CD4 (+) CD8 (−) | G/R |
| (M) | (>90% lymphoblasts) | B220 (−) | |||||
Abbreviations: M, male; F, female; Thy, thymus; Spl, spleen; LN, lymph node; WBC, white blood cell count; G, germline; R, rearranged.