Increased Production of IL-6 in Neonatal Monocytes Compared With Adult Monocytes
| . | Cord Blood (n = 20) . | Adult Blood (n = 30) . | P Value* . |
|---|---|---|---|
| IL-6 producing cells (%) | 63 (57-66) | 50 (42-60) | <.001 |
| IL-6 expression per cell (MFI) | 14 (13-16) | 9 (8-10) | <.0001 |
| . | Cord Blood (n = 20) . | Adult Blood (n = 30) . | P Value* . |
|---|---|---|---|
| IL-6 producing cells (%) | 63 (57-66) | 50 (42-60) | <.001 |
| IL-6 expression per cell (MFI) | 14 (13-16) | 9 (8-10) | <.0001 |
Values are expressed as the median of cytokine producing cells (%) and the cytokine expression per cell (mean fluorescence intensity [MFI]), with the interquartile range in parentheses. After stimulation with lipopolysaccharide, the production of IL-6 is significantly higher in cord blood than in adult blood monocytes analyzed at the single-cell level by flow cytometry.
Statistical differences comparing the two groups were tested by the nonparametric Mann-Whitney U test.