Percentage of CD41+ Cells Within the CD34+ Low Side-Scatter Population From PBPC Products by rhTPO Dose Level
| rhTPO (μg/kg) . | PBPCd1 . | PBPCd2 . | ||||||
|---|---|---|---|---|---|---|---|---|
| CD41+ Cells (%) . | CD34+ 106/kg (%) . | CD41+ Cells (%) . | CD34+ 106/kg (%) . | |||||
| Median . | Range . | Median . | Range . | Median . | Range . | Median . | Range . | |
| Arm A | ||||||||
| 0.6 × 15-150 | 9 | 6.1 | 19 | 7.9 | ||||
| 1.2 × 1 | 48 | 29-74 | 3.4 | 2.8-6.1 | 64 | 14-79 | 5.9 | 2.4-7.1 |
| 2.4 × 1 | 58 | 19-65 | 3.9 | 1.7-6.8 | 67.5 | 10-68 | 5.0 | 2.2-7.2 |
| Arm B | ||||||||
| 0.3 × 3 | 22 | 9-64 | 4.9 | 1.7-6.6 | 51 | 18-78 | 5.3 | 1.8-7.6 |
| 0.6 × 3 | 68 | 23-89 | 8.1 | 3.4-18.1 | 70.5 | 50-97 | 4.6 | 3-7.9 |
| Arm C | ||||||||
| 0.6 × 2 | 24 | 4-31 | 2.5 | 2.2-4 | 26 | 9-40 | 2.7 | 1.1-4.2 |
| rhTPO (μg/kg) . | PBPCd1 . | PBPCd2 . | ||||||
|---|---|---|---|---|---|---|---|---|
| CD41+ Cells (%) . | CD34+ 106/kg (%) . | CD41+ Cells (%) . | CD34+ 106/kg (%) . | |||||
| Median . | Range . | Median . | Range . | Median . | Range . | Median . | Range . | |
| Arm A | ||||||||
| 0.6 × 15-150 | 9 | 6.1 | 19 | 7.9 | ||||
| 1.2 × 1 | 48 | 29-74 | 3.4 | 2.8-6.1 | 64 | 14-79 | 5.9 | 2.4-7.1 |
| 2.4 × 1 | 58 | 19-65 | 3.9 | 1.7-6.8 | 67.5 | 10-68 | 5.0 | 2.2-7.2 |
| Arm B | ||||||||
| 0.3 × 3 | 22 | 9-64 | 4.9 | 1.7-6.6 | 51 | 18-78 | 5.3 | 1.8-7.6 |
| 0.6 × 3 | 68 | 23-89 | 8.1 | 3.4-18.1 | 70.5 | 50-97 | 4.6 | 3-7.9 |
| Arm C | ||||||||
| 0.6 × 2 | 24 | 4-31 | 2.5 | 2.2-4 | 26 | 9-40 | 2.7 | 1.1-4.2 |
Available only from 1 patient at this dose level.