Effects of Fenofibrate on Plasma Fibrinogen Levels in PPAR-Null (−/−) and Wild-Type (+/+) Mice
| Treatment . | Fibrinogen (g/L) . | |
|---|---|---|
| Wild-Type (+/+) . | PPARα-Null (−/−) . | |
| Control (n = 7) | 2.67 ± 0.42 | 3.20 ± 0.48* |
| Fenofibrate (n = 7) | 2.06 ± 0.26 | 2.87 ± 0.23* |
| Difference | −0.61 ± 0.31 | −0.33 ± 0.36 |
| (P = .007) | (P = .13) | |
| Treatment . | Fibrinogen (g/L) . | |
|---|---|---|
| Wild-Type (+/+) . | PPARα-Null (−/−) . | |
| Control (n = 7) | 2.67 ± 0.42 | 3.20 ± 0.48* |
| Fenofibrate (n = 7) | 2.06 ± 0.26 | 2.87 ± 0.23* |
| Difference | −0.61 ± 0.31 | −0.33 ± 0.36 |
| (P = .007) | (P = .13) | |
Wild-type (+/+) and PPARα-null (−/−) mice (n = 7) were treated with 0.2% (wt/wt) fenofibrate mixed in chow for 17 days. Values are means ± SD.
Statistically significant (P < .05) difference between wild-type versus PPARα-null mice.