Table 2. Unfavorable Prognostic Factors... | American Society of Hematology

Table 2.

Unfavorable Prognostic Factors for OS in 201 Patients With De Novo AML Except M3

Prognostic Factors	Univariate	Multivariate
Prognostic Factors	P Value	P Value	Relative Risk (95% CI)
Age, 60 yr or older	.0002	.002	1.9 (1.2-2.6)
Cytogenetics^*	.002	.004	2.6^†
FAB other than M2	.002	.2
WBC count >100 × 10⁹/L	.003	.2
FLT3 gene mutation	.004	.1
N-RAS gene mutation	.06	.6

Prognostic Factors	Univariate	Multivariate
Prognostic Factors	P Value	P Value	Relative Risk (95% CI)
Age, 60 yr or older	.0002	.002	1.9 (1.2-2.6)
Cytogenetics^*	.002	.004	2.6^†
FAB other than M2	.002	.2
WBC count >100 × 10⁹/L	.003	.2
FLT3 gene mutation	.004	.1
N-RAS gene mutation	.06	.6

Karyotypes were segregated into four groups: a good-risk group with t(8;21) or inv(16); a poor-risk group with t(9;22), 11q23 alterations, del(5) or del(7); a standard-risk group with normal or other karyotypes; and a karyotype-unknown group.

†

Comparison between the good-risk and poor-risk groups.

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