Table 1. Clinical Characteristics of 201... | American Society of Hematology

Table 1.

Clinical Characteristics of 201 Patients With De Novo AML Except M3

	Total (N = 201)	Mutant FLT3/ Mutant N-RAS (N = 3)	Mutant FLT3/ Wild N-RAS (N = 43)	Wild FLT3/ Mutant N-RAS (N = 25)	Wild FLT3/ Wild N-RAS (N = 130)
Age	49	60	56	45	48.5
		(41-64)	(15-77)	(16-82)	(15-85)
WBC (10⁹/L)	24.7	120^*	52.2^‡	67.8^†	19.3
		(50.2-372)	(2.1-632)	(5.3-234)	(0.9-33.7)
FAB
M0	3	0	0	1	2
M1	48	2	12	4	30
M2	83	1	7^*	9	66
M4	47	0	17	11	19
M5	15	0	5	0	10
M6	4	0	1	0	3
M7	1	0	1	0	0
Cytogenetics
t(8;21)	28	0	2^*	1	25
inv(16)	6	0	2	0	4
t(9;22)	3	0	0	1	2
del(5) or del(7)	11	0	2	2	7
Others	41	0	5	7	29
Normal	82	3	20	12	47
ND	30	0	11	2	17
Outcome
CR	147	2	30	13^†	102
Failure	51	0	13	12^†	26
Unevaluable	3	1	0	0	2

	Total (N = 201)	Mutant FLT3/ Mutant N-RAS (N = 3)	Mutant FLT3/ Wild N-RAS (N = 43)	Wild FLT3/ Mutant N-RAS (N = 25)	Wild FLT3/ Wild N-RAS (N = 130)
Age	49	60	56	45	48.5
		(41-64)	(15-77)	(16-82)	(15-85)
WBC (10⁹/L)	24.7	120^*	52.2^‡	67.8^†	19.3
		(50.2-372)	(2.1-632)	(5.3-234)	(0.9-33.7)
FAB
M0	3	0	0	1	2
M1	48	2	12	4	30
M2	83	1	7^*	9	66
M4	47	0	17	11	19
M5	15	0	5	0	10
M6	4	0	1	0	3
M7	1	0	1	0	0
Cytogenetics
t(8;21)	28	0	2^*	1	25
inv(16)	6	0	2	0	4
t(9;22)	3	0	0	1	2
del(5) or del(7)	11	0	2	2	7
Others	41	0	5	7	29
Normal	82	3	20	12	47
ND	30	0	11	2	17
Outcome
CR	147	2	30	13^†	102
Failure	51	0	13	12^†	26
Unevaluable	3	1	0	0	2

Mean (minimum to maximum) values are indicated in age and WBC. Number of cases are shown in FAB, cytogenetics, and outcome.

.1 > P > .01.

.01 > P > .001.

P < .001 compared with wild FLT3/wild N-RAS group.

Abbreviation: ND, not determined.