Clinical Findings of T/null Primary, Systemic ALK+ and ALK− Anaplastic Large-Cell Lymphoma
| Characteristic . | ALK+ (N = 53) . | ALK− (N = 25) . | P . |
|---|---|---|---|
| Sex | |||
| M | 40 | 12 | .016 |
| F | 13 | 13 | |
| Age (yr) | |||
| ≤35 | 47 | 10 | .001 |
| >35 | 6 | 15 | |
| Performance status | |||
| 0-1 | 25 | 16 | NS |
| >1 | 21 | 7 | |
| B symptoms | |||
| No | 13 | 10 | NS |
| Yes | 40 | 15 | |
| Bulky disease | |||
| No | 40 | 15 | NS |
| Yes | 13 | 10 | |
| Extranodal sites | |||
| No | 21 | 17 | .019 |
| Yes | 32 | 8 | |
| Extranodal sites | |||
| Skin | 11 | 1 | |
| Bone | 9 | 1 | |
| Bone marrow | 6 | 0 | |
| PB | 3 | 0 | |
| Lung | 6 | 0 | |
| Liver | 4 | 1 | |
| Pleura | 3 | 0 | |
| Soft tissues | 9 | 0 | |
| Muscle | 3 | 0 | |
| CNS | 2 | 0 | |
| Gut | 1 | 1 | |
| Testicle | 1 | 0 | |
| Parotid | 1 | 0 | |
| Ann Arbor stage | |||
| I-II | 15 | 14 | .018 |
| III-IV | 38 | 11 | |
| LDH level | |||
| <1× normal | 27 | 13 | NS |
| >1× normal | 20 | 10 | |
| International Prognostic Index | |||
| 0-1 (low/low intermediate) | 25 | 17 | NS |
| ≥2 (high/high intermediate) | 25 | 7 |
| Characteristic . | ALK+ (N = 53) . | ALK− (N = 25) . | P . |
|---|---|---|---|
| Sex | |||
| M | 40 | 12 | .016 |
| F | 13 | 13 | |
| Age (yr) | |||
| ≤35 | 47 | 10 | .001 |
| >35 | 6 | 15 | |
| Performance status | |||
| 0-1 | 25 | 16 | NS |
| >1 | 21 | 7 | |
| B symptoms | |||
| No | 13 | 10 | NS |
| Yes | 40 | 15 | |
| Bulky disease | |||
| No | 40 | 15 | NS |
| Yes | 13 | 10 | |
| Extranodal sites | |||
| No | 21 | 17 | .019 |
| Yes | 32 | 8 | |
| Extranodal sites | |||
| Skin | 11 | 1 | |
| Bone | 9 | 1 | |
| Bone marrow | 6 | 0 | |
| PB | 3 | 0 | |
| Lung | 6 | 0 | |
| Liver | 4 | 1 | |
| Pleura | 3 | 0 | |
| Soft tissues | 9 | 0 | |
| Muscle | 3 | 0 | |
| CNS | 2 | 0 | |
| Gut | 1 | 1 | |
| Testicle | 1 | 0 | |
| Parotid | 1 | 0 | |
| Ann Arbor stage | |||
| I-II | 15 | 14 | .018 |
| III-IV | 38 | 11 | |
| LDH level | |||
| <1× normal | 27 | 13 | NS |
| >1× normal | 20 | 10 | |
| International Prognostic Index | |||
| 0-1 (low/low intermediate) | 25 | 17 | NS |
| ≥2 (high/high intermediate) | 25 | 7 |
Abbreviation: NS, not significant.