Proliferative Responses to the Immunological Carrier KLH
| Patient (UPN) . | Onset of KLH Response . | Peak KLH Response . | cpm at Time of Peak Response3-150 . |
|---|---|---|---|
| 1 (1172) | Post Id/KLH#3 | Post Id/KLH#5 | 177,315 ± 19,518 |
| 2 (1243) | Post Id/KLH#1 | Post Id/KLH#5 | 141,310 ± 4,909 |
| 3 (1289) | Post Id/KLH#1 | Post Id/KLH#1 | 127,250 ± 15,890 |
| 4 (1353) | Post Id/KLH#1 | Post Id/KLH#2 | 58,188 ± 6,561 |
| 5 (1397) | Post Id/KLH#1 | Post Id/KLH#4 | 225,485 ± 2,887 |
| 6 (1396) | Post Id/KLH#1 | Post Id/KLH#5 | 43,465 ± 10,977 |
| 7 (1445) | No KLH response | No KLH response | Background |
| 8 (1441) | Post Id/KLH#3 | Post Id/KLH#4 | 73,815 ± 6,372 |
| 9 (1457) | Post Id/KLH#2 | Post Id/KLH#4 | 14,939 ± 3,198 |
| 10 (1483) | Post Id/KLH#1 | Post Id/KLH#1 | 354,117 ± 4,783 |
| 11 (1504) | Post Id/KLH#2 | Post Id/KLH#3 | 117,556 ± 6,410 |
| 12 (1521) | Post Id/KLH#2 | Post Id/KLH#3 | 83,213 ± 11,185 |
| Patient (UPN) . | Onset of KLH Response . | Peak KLH Response . | cpm at Time of Peak Response3-150 . |
|---|---|---|---|
| 1 (1172) | Post Id/KLH#3 | Post Id/KLH#5 | 177,315 ± 19,518 |
| 2 (1243) | Post Id/KLH#1 | Post Id/KLH#5 | 141,310 ± 4,909 |
| 3 (1289) | Post Id/KLH#1 | Post Id/KLH#1 | 127,250 ± 15,890 |
| 4 (1353) | Post Id/KLH#1 | Post Id/KLH#2 | 58,188 ± 6,561 |
| 5 (1397) | Post Id/KLH#1 | Post Id/KLH#4 | 225,485 ± 2,887 |
| 6 (1396) | Post Id/KLH#1 | Post Id/KLH#5 | 43,465 ± 10,977 |
| 7 (1445) | No KLH response | No KLH response | Background |
| 8 (1441) | Post Id/KLH#3 | Post Id/KLH#4 | 73,815 ± 6,372 |
| 9 (1457) | Post Id/KLH#2 | Post Id/KLH#4 | 14,939 ± 3,198 |
| 10 (1483) | Post Id/KLH#1 | Post Id/KLH#1 | 354,117 ± 4,783 |
| 11 (1504) | Post Id/KLH#2 | Post Id/KLH#3 | 117,556 ± 6,410 |
| 12 (1521) | Post Id/KLH#2 | Post Id/KLH#3 | 83,213 ± 11,185 |
All patients except patients 7 and 10 were vaccinated with two Id-pulsed DC vaccines followed by five Id/KLH vaccines at 4-week intervals. PBMNC samples were stimulated for 6 days in medium containing KLH. Results with the highest KLH concentration investigated (100 μg/mL) are reported as average of triplicate or quadruplicate wells ± 1 SD. 3H thymidine incorporation is reported as counts per minute (cpm). Background proliferation in medium was less than 1,500 cpm.