Comparison of Tissue-Associated Radioactivity in Control and Thrombocytopenic Mice
| . | CD-1 Mice . | W/B F1 . | ||||
|---|---|---|---|---|---|---|
| Control (n = 8) . | Irradiated (n = 5) . | 1 d RAMPS (n = 6) . | 5 d RAMPS (n = 6) . | Male (n = 6) . | Female Control (n = 3) . | |
| Femur | 14.9 ± 2.3 | 12.6 ± 2.7 | 24.8 ± 5.1*,† | 19.6 ± 6.5 | 15.8 ± 7.5 | 17.5 ± 3.3 |
| Heart | 17.6 ± 3.2 | 19.7 ± 3.0 | 15.9 ± 2.7 | 12.4 ± 2.8 | 14.9 ± 5.2‡ | 33.4 ± 6.5 |
| Kidney | 25.9 ± 2.6 | 31.2 ± 3.8 | 29.2 ± 5.0 | 22.6 ± 3.8 | 28.9 ± 4.5‡ | 40.4 ± 7.7 |
| Liver | 15.9 ± 2.2 | 17.1 ± 1.2 | 19.0 ± 3.5 | 14.7 ± 2.0 | 19.5 ± 4.75‡ | 28.6 ± 5.7 |
| Lung | 47.3 ± 9.7 | 43.7 ± 12.4 | 42.7 ± 13.6 | 33.7 ± 6.8 | 33.5 ± 10.5‡ | 63.3 ± 15.3 |
| Spleen | 160 ± 24.7 | 18.0 ± 3.01-153 | 65.1 ± 24.1 | 46.0 ± 11.7* | 43.9 ± 13.1‡ | 180.9 ± 51.7 |
| Sternum | 12.8 ± 3.9 | 13.4 ± 3.5 | 21.5 ± 4.9*,† | 17.2 ± 5.16 | 15.8 ± 7.6 | 17.3 ± 0.7 |
| Whole blood | 92.1 ± 9.7 | 131.3 ± 14.61-155 | 97.8 ± 22.0 | 74.0 ± 15.9† | 69.9 ± 17.1‡ | 128.0 ± 18.3 |
| Washed cells | 49.9 ± 7.9 | 5.2 ± 1.5* | 3.6 ± 1.2* | 5.3 ± 1.6* | 16.6 ± 10.4‡ | 61.5 ± 16.8 |
| Plasma ppt | 35.1 ± 9.0 | 105.4 ± 12.5* | 72.0 ± 16.1* | 42.4 ± 9.6† | 38.8 ± 10.7 | 39.5 ± 11.0 |
| PLT nadir | 1,157.5 ± 91.6 | 105.7 ± 35.5 | 48.4 ± 14.3 | 75.2 ± 17.3 | 476.7 ± 260.9 | 1,313 ± 287 |
| Body weight | 27.0 ± 0.9 | 27.0 ± 0.6 | 26.5 ± 2.1 | 27.0 ± 1.0 | 31.0 ± 2.2 | 26.8 ± 2.2 |
| . | CD-1 Mice . | W/B F1 . | ||||
|---|---|---|---|---|---|---|
| Control (n = 8) . | Irradiated (n = 5) . | 1 d RAMPS (n = 6) . | 5 d RAMPS (n = 6) . | Male (n = 6) . | Female Control (n = 3) . | |
| Femur | 14.9 ± 2.3 | 12.6 ± 2.7 | 24.8 ± 5.1*,† | 19.6 ± 6.5 | 15.8 ± 7.5 | 17.5 ± 3.3 |
| Heart | 17.6 ± 3.2 | 19.7 ± 3.0 | 15.9 ± 2.7 | 12.4 ± 2.8 | 14.9 ± 5.2‡ | 33.4 ± 6.5 |
| Kidney | 25.9 ± 2.6 | 31.2 ± 3.8 | 29.2 ± 5.0 | 22.6 ± 3.8 | 28.9 ± 4.5‡ | 40.4 ± 7.7 |
| Liver | 15.9 ± 2.2 | 17.1 ± 1.2 | 19.0 ± 3.5 | 14.7 ± 2.0 | 19.5 ± 4.75‡ | 28.6 ± 5.7 |
| Lung | 47.3 ± 9.7 | 43.7 ± 12.4 | 42.7 ± 13.6 | 33.7 ± 6.8 | 33.5 ± 10.5‡ | 63.3 ± 15.3 |
| Spleen | 160 ± 24.7 | 18.0 ± 3.01-153 | 65.1 ± 24.1 | 46.0 ± 11.7* | 43.9 ± 13.1‡ | 180.9 ± 51.7 |
| Sternum | 12.8 ± 3.9 | 13.4 ± 3.5 | 21.5 ± 4.9*,† | 17.2 ± 5.16 | 15.8 ± 7.6 | 17.3 ± 0.7 |
| Whole blood | 92.1 ± 9.7 | 131.3 ± 14.61-155 | 97.8 ± 22.0 | 74.0 ± 15.9† | 69.9 ± 17.1‡ | 128.0 ± 18.3 |
| Washed cells | 49.9 ± 7.9 | 5.2 ± 1.5* | 3.6 ± 1.2* | 5.3 ± 1.6* | 16.6 ± 10.4‡ | 61.5 ± 16.8 |
| Plasma ppt | 35.1 ± 9.0 | 105.4 ± 12.5* | 72.0 ± 16.1* | 42.4 ± 9.6† | 38.8 ± 10.7 | 39.5 ± 11.0 |
| PLT nadir | 1,157.5 ± 91.6 | 105.7 ± 35.5 | 48.4 ± 14.3 | 75.2 ± 17.3 | 476.7 ± 260.9 | 1,313 ± 287 |
| Body weight | 27.0 ± 0.9 | 27.0 ± 0.6 | 26.5 ± 2.1 | 27.0 ± 1.0 | 31.0 ± 2.2 | 26.8 ± 2.2 |
Tissue-associated radioactivity is presented as cpm × 10−4/per gram (mL) of tissue (whole blood or plasma; mean ± SD). PLT nadir is presented as count × 10−3/mL (mean ± SD). Body weight is presented in grams (mean ± SD).
Abbreviation: plasma ppt, TCA-precipitable plasma-associated radioactivity.
P < .05 when compared with CD-1 control.
P < .05 when compared with irradiated.
P < .05 when compared with F1 female control.
P < .001 when compared with CD-1 control.
P < .01 when compared with CD-1 control.