Conserved Components of the Notch Signaling Pathway
| . | C elegans . | Drosophila . | Mammals . | . |
|---|---|---|---|---|
| NOTCH receptors | Lin-12 Glp-1 | Notch | Notch1 Notch3 Notch2 Notch4 | |
| Extracellular ligands (DSL proteins) | Lag-2 Apx-1 | Delta | Delta-1 Delta-1 Delta-like 1 (DII-1) Delta-like 3 (DII-3) | |
| Serrate | Jagged1 (Serrate1) Jagged2 (Serrate2) | |||
| Intracellular effectors | Lag-1 | Suppressor of Hairless [Su(H)] | CBF-1/RBP-Jκ | |
| Deltex | Deltex NFκB | |||
| Target genes | Enhancer of split [E(spl)] | HES (Hairy/Enhancer of split) | ||
| bHLH | bHLH | |||
| Groucho | TLE | |||
| Processing molecules | SUP-17 | Kuzbanian | Kuzbanian | |
| Modifiers | Fringe | Lunatic Fringe | ||
| Manic Fringe | ||||
| Radical Fringe | ||||
| Numb | Numb | |||
| Numb-like | ||||
| Dishevelled | Dishevelled 1,2,3 |
| . | C elegans . | Drosophila . | Mammals . | . |
|---|---|---|---|---|
| NOTCH receptors | Lin-12 Glp-1 | Notch | Notch1 Notch3 Notch2 Notch4 | |
| Extracellular ligands (DSL proteins) | Lag-2 Apx-1 | Delta | Delta-1 Delta-1 Delta-like 1 (DII-1) Delta-like 3 (DII-3) | |
| Serrate | Jagged1 (Serrate1) Jagged2 (Serrate2) | |||
| Intracellular effectors | Lag-1 | Suppressor of Hairless [Su(H)] | CBF-1/RBP-Jκ | |
| Deltex | Deltex NFκB | |||
| Target genes | Enhancer of split [E(spl)] | HES (Hairy/Enhancer of split) | ||
| bHLH | bHLH | |||
| Groucho | TLE | |||
| Processing molecules | SUP-17 | Kuzbanian | Kuzbanian | |
| Modifiers | Fringe | Lunatic Fringe | ||
| Manic Fringe | ||||
| Radical Fringe | ||||
| Numb | Numb | |||
| Numb-like | ||||
| Dishevelled | Dishevelled 1,2,3 |