Extent of Fibrin Deposition as Detected by Immunostaining in Kidney Sections of 2-AP+/+ and 2-AP−/− Mice, 4 or 8 Hours After Injection of 2 mg/kg Endotoxin
| . | Score4-150 . | |||
|---|---|---|---|---|
| 0 . | 1 . | 2 . | 3 . | |
| Cortex/glomeruli | ||||
| 4 h | ||||
| α2-AP+/+ | 11 | 0 | 1 | 4 |
| α2-AP−/− | 15 | 1 | 0 | 0 |
| 8 h | ||||
| α2-AP+/+ | 9 | 1 | 2 | 4 |
| α2-AP−/− | 15 | 0 | 0 | 0 |
| Medulla/capillaries | ||||
| 4 h | ||||
| α2-AP+/+ | 2 | 2 | 3 | 9 |
| α2-AP−/− | 6 | 6 | 4 | 0 |
| 8 h | ||||
| α2-AP+/+ | 2 | 3 | 4 | 7 |
| α2-AP−/− | 11 | 4 | 0 | 0 |
| . | Score4-150 . | |||
|---|---|---|---|---|
| 0 . | 1 . | 2 . | 3 . | |
| Cortex/glomeruli | ||||
| 4 h | ||||
| α2-AP+/+ | 11 | 0 | 1 | 4 |
| α2-AP−/− | 15 | 1 | 0 | 0 |
| 8 h | ||||
| α2-AP+/+ | 9 | 1 | 2 | 4 |
| α2-AP−/− | 15 | 0 | 0 | 0 |
| Medulla/capillaries | ||||
| 4 h | ||||
| α2-AP+/+ | 2 | 2 | 3 | 9 |
| α2-AP−/− | 6 | 6 | 4 | 0 |
| 8 h | ||||
| α2-AP+/+ | 2 | 3 | 4 | 7 |
| α2-AP−/− | 11 | 4 | 0 | 0 |
Four sections were analyzed of kidneys of 4 different animals.
Score 0, no fibrin deposits; score 1, a few small, weakly stained fibrin deposits; score 2, clearly stained, small fibrin deposits; score 3, large, strongly stained fibrin deposits.