Immunophenotype of B-CLL Cells Stimulated by CD40L
| Patient . | Recognition . | Adhesion . | Costimulation . | ||||
|---|---|---|---|---|---|---|---|
| MHC I . | MHC II . | ICAM-1 . | LFA-3 . | B7-1 . | B7-2 . | CD40 . | |
| CLL-1 | +++ | ++++ | ++ | + | ++ | ++++ | ++ |
| CLL-2 | ND | ++++ | ++ | ++ | ++ | +++ | ++ |
| CLL-3 | ND | +++ | ++ | + | + | +++ | +++ |
| CLL-4 | ND | ++++ | +++ | ++ | ++ | +++ | ++ |
| CLL-5 | +++ | ++++ | +++ | +++ | +++ | ++++ | +++ |
| CLL-6 | +++ | ++++ | ++ | +++ | ++ | +++ | +++ |
| CLL-7 | ND | +++ | ++ | ++ | ++ | +++ | ++ |
| CLL-8 | ++++ | ++++ | +++ | ++ | + | +++ | ++ |
| CLL-9 | +++ | ++++ | +++ | ++ | ++ | +++ | ++ |
| CLL-10 | ++++ | ++++ | +++ | ++ | + | +++ | ++ |
| CLL-11 | ++++ | ++++ | +++ | +++ | ++ | +++ | ++ |
| CLL-12 | ++++ | +++ | +++ | +++ | ++ | +++ | ++ |
| Patient . | Recognition . | Adhesion . | Costimulation . | ||||
|---|---|---|---|---|---|---|---|
| MHC I . | MHC II . | ICAM-1 . | LFA-3 . | B7-1 . | B7-2 . | CD40 . | |
| CLL-1 | +++ | ++++ | ++ | + | ++ | ++++ | ++ |
| CLL-2 | ND | ++++ | ++ | ++ | ++ | +++ | ++ |
| CLL-3 | ND | +++ | ++ | + | + | +++ | +++ |
| CLL-4 | ND | ++++ | +++ | ++ | ++ | +++ | ++ |
| CLL-5 | +++ | ++++ | +++ | +++ | +++ | ++++ | +++ |
| CLL-6 | +++ | ++++ | ++ | +++ | ++ | +++ | +++ |
| CLL-7 | ND | +++ | ++ | ++ | ++ | +++ | ++ |
| CLL-8 | ++++ | ++++ | +++ | ++ | + | +++ | ++ |
| CLL-9 | +++ | ++++ | +++ | ++ | ++ | +++ | ++ |
| CLL-10 | ++++ | ++++ | +++ | ++ | + | +++ | ++ |
| CLL-11 | ++++ | ++++ | +++ | +++ | ++ | +++ | ++ |
| CLL-12 | ++++ | +++ | +++ | +++ | ++ | +++ | ++ |
Mean intensity of fluorescence: −, negative; +, >0.2-0.5 logarithm; ++, 0.5-1.5 logarithm; +++, 1.5-2.5 logarithm; ++++, >2.5 logarithm; ND, not done.