Tolerization for Gaucher Patients Treated With Alglucerase
| Time Postinitiation of Therapy . | Tolerized . | Nontolerized . | % Tolerized . |
|---|---|---|---|
| >12 months therapy (n = 122) | 82 | 40 | 62.7 |
| >30 months therapy (n = 69) | 64 | 5 | 93 |
| Time Postinitiation of Therapy . | Tolerized . | Nontolerized . | % Tolerized . |
|---|---|---|---|
| >12 months therapy (n = 122) | 82 | 40 | 62.7 |
| >30 months therapy (n = 69) | 64 | 5 | 93 |
A decrease and ultimately absence of antibody to GCR (tolerization) was noted in seroconverted patients on prolonged treatment with alglucerase. A patient was considered tolerized if after seroconversion, both ELISA and RIP of subsequent sera samples were negative.