Computer Analysis of Gold Particle Density on Platelet Sections
| Localization of c7E3 . | During Infusion . | <48 h After Infusion . | >48 h After Infusion . | |||
|---|---|---|---|---|---|---|
| No. of Particles per Section . | Linear Density . | No. of Particles per Section . | Linear Density . | No. of Particles per Section . | Linear Density . | |
| At the platelet surface | 75.10 ± 10.48 | 8.85 ± 0.32 | 61.49 ± 16.85 | 8.84 ± 2.85 | 33.87 ± 5.52 | 4.88 ± 1.81 |
| NS | (P < .001) | |||||
| Inside the platelet | 24.64 ± 7.58 | 24.38 ± 9.47 | 17.16 ± 10.95 | |||
| NS | NS | |||||
| Total | 99.74 ± 15.7 | 85.87 ± 23.53 | 51.03 ± 14.99 | |||
| NS | (P < .051) | |||||
| Percentage inside the platelets | 24.26 ± 4.94 | 28.21 ± 6.24 | 31.33 ± 11.06 | |||
| NS | NS | |||||
| Localization of c7E3 . | During Infusion . | <48 h After Infusion . | >48 h After Infusion . | |||
|---|---|---|---|---|---|---|
| No. of Particles per Section . | Linear Density . | No. of Particles per Section . | Linear Density . | No. of Particles per Section . | Linear Density . | |
| At the platelet surface | 75.10 ± 10.48 | 8.85 ± 0.32 | 61.49 ± 16.85 | 8.84 ± 2.85 | 33.87 ± 5.52 | 4.88 ± 1.81 |
| NS | (P < .001) | |||||
| Inside the platelet | 24.64 ± 7.58 | 24.38 ± 9.47 | 17.16 ± 10.95 | |||
| NS | NS | |||||
| Total | 99.74 ± 15.7 | 85.87 ± 23.53 | 51.03 ± 14.99 | |||
| NS | (P < .051) | |||||
| Percentage inside the platelets | 24.26 ± 4.94 | 28.21 ± 6.24 | 31.33 ± 11.06 | |||
| NS | NS | |||||
Mean values are for a minimum of 10 sections for patients 1, 2, and 3 at each time point (see Fig 1) counted as described in Materials and Methods. Results are grouped as shown. The decrease in the number of gold particles at the platelet surface was not significant during the first 48 hours after the end of the c7E3 infusion, but after 48 hours it was significant. Findings were similar for the total number of gold particles, and the tendency was the same for gold particles present inside the platelets although the difference after 48 hours was not significant due to the greater heterogeneity between platelets.
Abbreviation: NS, not significant.