Hemostatic Parameters of VN +/+ Mice and VN −/− Mice
| Parameter . | VN +/+ . | VN −/− . | PValue . |
|---|---|---|---|
| Platelet count (×109mL) | 1.18 | 1.21 | |
| Hematocrit (%) | 38.9 | 37.8 | |
| APTT (seconds) | 31.3 ± 0.5 (4) | 30.5 ± 0.4 (4) | >5 |
| Reptilase time (seconds) | 40.6 ± 5.8 (4) | 38.4 ± 1.0 (4) | >.5 |
| Tail bleeding assay (mL blood loss) | 0.52 ± .05 (5) | 0.43 ± 0.04 (4) | >.3 |
| Plasma fibrinogen (% normal pooled plasma) | 100 ± 10.8 | 93.8 ± 7.2 | >.7 |
| FDP | Not detctable | Not detectable |
| Parameter . | VN +/+ . | VN −/− . | PValue . |
|---|---|---|---|
| Platelet count (×109mL) | 1.18 | 1.21 | |
| Hematocrit (%) | 38.9 | 37.8 | |
| APTT (seconds) | 31.3 ± 0.5 (4) | 30.5 ± 0.4 (4) | >5 |
| Reptilase time (seconds) | 40.6 ± 5.8 (4) | 38.4 ± 1.0 (4) | >.5 |
| Tail bleeding assay (mL blood loss) | 0.52 ± .05 (5) | 0.43 ± 0.04 (4) | >.3 |
| Plasma fibrinogen (% normal pooled plasma) | 100 ± 10.8 | 93.8 ± 7.2 | >.7 |
| FDP | Not detctable | Not detectable |
Platelet counts and hematocrits were measured with pooled, heparinized blood obtained from 3 mice. Fibrinogen was measured in triplicate with pooled, citrated plasma obtained from 4 mice. Fibrinogen/fibrin degradation products (FDP) were measured with pooled serum obtained from 5 mice. Other parameters were performed on individual samples obtained from the number of mice indicated in parentheses.