Table 3.

-ID Activity in Blood and Marrow Leukocytes and Individual CFU-GM Postinfusion

Dog Time Point PBL BML CFU-GM
M2  1 mo Negative  Negative  1/155  
M2  8 mo  Negative Negative  0/87  
M2  12 mo  Negative  Negative 0/85  
M2  24 mo  Negative  Negative  0/72  
M5 1 mo  Negative  Negative  0/90  
M5  4 mo Negative  Negative  0/103  
M2 untransduced control  Negative  Negative  0/100  
Normal dog control3-150  Positive  Positive  22/23 
Dog Time Point PBL BML CFU-GM
M2  1 mo Negative  Negative  1/155  
M2  8 mo  Negative Negative  0/87  
M2  12 mo  Negative  Negative 0/85  
M2  24 mo  Negative  Negative  0/72  
M5 1 mo  Negative  Negative  0/90  
M5  4 mo Negative  Negative  0/103  
M2 untransduced control  Negative  Negative  0/100  
Normal dog control3-150  Positive  Positive  22/23 

α-ID activity in BFU-E was not determined, because α-ID activity cannot be detected in BFU-E from normal dogs, likely due to interference of fluorescent measurements by hemoglobin.

F3-150

CFU-GM from a normal wild-type dog.

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