Prognostic Factors for PFS in Binet Stage A CLL Patients (N = 122)
| Parameter . | Univariate Analysis . | Multiple Regression (Cox) Analysis . | ||
|---|---|---|---|---|
| Cut-Off Level . | P* . | Relative Risk . | P . | |
| s-TK | 7.1 U/l | <.0001 | 3.44 | <.0001 |
| Presence of lymphadenopathy | Yes v no | <.0001 | 3.64 | <.0001 |
| WBC count | 75,000/μL | .0072 | 4.82 | .0040 |
| Lymphocyte doubling time | 6.5 mo | <.0001 | ||
| Serum IgA | 40 mg/dL | <.0001 | ||
| Peripheral blood lymphocyte count | 44,275/μL | <.0001 | ||
| s-β2M | 2.05 mg/L | <.0001 | ||
| Serum IgM | 37 mg/dL | .0001 | ||
| Platelet count | 133,500/μL | .0004 | ||
| Rai stage | 0 v I + II | .0004 | ||
| Interferon-alfa treatment | Yes v no | .0014 | ||
| Serum LDH | 202 U/L | .0037 | ||
| Serum IgG | 635 mg/dL | .0045 | ||
| Presence of splenomegaly | Yes v no | .014 | ||
| Diagnosis to study interval | 38 mo | .032 | ||
| Peripheral blood neutrophil count | 8,300/μL | .033 | ||
| Bone marrow histology | Nodular v nonnodular | .035 | ||
| Blood hemoglobin | 14.3 g/dL | .042 | ||
| Presence of hepatomegaly | Yes v no | >.05 | ||
| Age | 58.5 yr | >.05 | ||
| Sex | Male v female | >.05 | ||
| Performance status (ECOG) | 0 v 1 | >.05 | ||
| Parameter . | Univariate Analysis . | Multiple Regression (Cox) Analysis . | ||
|---|---|---|---|---|
| Cut-Off Level . | P* . | Relative Risk . | P . | |
| s-TK | 7.1 U/l | <.0001 | 3.44 | <.0001 |
| Presence of lymphadenopathy | Yes v no | <.0001 | 3.64 | <.0001 |
| WBC count | 75,000/μL | .0072 | 4.82 | .0040 |
| Lymphocyte doubling time | 6.5 mo | <.0001 | ||
| Serum IgA | 40 mg/dL | <.0001 | ||
| Peripheral blood lymphocyte count | 44,275/μL | <.0001 | ||
| s-β2M | 2.05 mg/L | <.0001 | ||
| Serum IgM | 37 mg/dL | .0001 | ||
| Platelet count | 133,500/μL | .0004 | ||
| Rai stage | 0 v I + II | .0004 | ||
| Interferon-alfa treatment | Yes v no | .0014 | ||
| Serum LDH | 202 U/L | .0037 | ||
| Serum IgG | 635 mg/dL | .0045 | ||
| Presence of splenomegaly | Yes v no | .014 | ||
| Diagnosis to study interval | 38 mo | .032 | ||
| Peripheral blood neutrophil count | 8,300/μL | .033 | ||
| Bone marrow histology | Nodular v nonnodular | .035 | ||
| Blood hemoglobin | 14.3 g/dL | .042 | ||
| Presence of hepatomegaly | Yes v no | >.05 | ||
| Age | 58.5 yr | >.05 | ||
| Sex | Male v female | >.05 | ||
| Performance status (ECOG) | 0 v 1 | >.05 | ||
Log-rank test.