Processing of PBPCs: Total of All Leukaphereses
| Processing Step . | Processing Variable . | P Value . | |
|---|---|---|---|
| CD34-Selected Arm (n = 67) . | Unselected Arm (n = 64) . | ||
| CD34+ cells/kg | |||
| Product at start (×106) | n = 60 | n = 56 | |
| Median | 10.13 | 8.67 | .253 |
| Range | 0-81.29 | 0.68-76.18 | |
| Selected product (×106) | n = 61 | ||
| Median | 5.40 | NA | .012 |
| Range | 0.03-24.79 | ||
| CFU-GM/kg | |||
| Product at start (×104) | n = 58 | n = 49 | |
| Median | 88.21 | 112.35 | .704 |
| Range | 0-532.28 | 1.97-936.4 | |
| Selected product (×104) | n = 58 | ||
| Median | 59.8 | NA | .287 |
| Range | 0-634.58 | ||
| Processing Step . | Processing Variable . | P Value . | |
|---|---|---|---|
| CD34-Selected Arm (n = 67) . | Unselected Arm (n = 64) . | ||
| CD34+ cells/kg | |||
| Product at start (×106) | n = 60 | n = 56 | |
| Median | 10.13 | 8.67 | .253 |
| Range | 0-81.29 | 0.68-76.18 | |
| Selected product (×106) | n = 61 | ||
| Median | 5.40 | NA | .012 |
| Range | 0.03-24.79 | ||
| CFU-GM/kg | |||
| Product at start (×104) | n = 58 | n = 49 | |
| Median | 88.21 | 112.35 | .704 |
| Range | 0-532.28 | 1.97-936.4 | |
| Selected product (×104) | n = 58 | ||
| Median | 59.8 | NA | .287 |
| Range | 0-634.58 | ||
Processing data were evaluated for CD34+ cells per kilogram and CFU-GM per kilogram on patients who had data available for every leukapheresis and at each specific processing step. For patients in the CD34 selected arm, the selected product was cryopreserved; for patients in the unselected arm, the product at start was cryopreserved. The patients in the CD34-selected arm had significantly fewer CD34+ cells per kilogram infused (P = .012). There was no significant difference between the arms in the number of CFU-GM per kilogram infused (P = .287).
Abbreviation: NA, not applicable.