Relationship Between CYP1A1, CYP2D6, GSTM1, and GSTT1 Genotypes and Risk of Childhood ALL
| Gene . | Genotype . | OR . | 95% CI . | P . |
|---|---|---|---|---|
| CYP1A13-151 | *2A | 1.8 | 1.1-3.1 | .033-155 |
| *2B | 0.9 | 0.4-1.8 | .90 | |
| *4 | 0.6 | 0.3-1.2 | .16 | |
| CYP2D63-152 | *3 | 5.5 | 0.6-53.4 | .13 |
| *4 | 1.6 | 0.6-4.1 | .40 | |
| PM | 1.8 | 0.8-4.4 | .17 | |
| GSTM13-153 | Null | 1.8 | 1.2-2.6 | .0043-155 |
| GSTT13-153 | Null | 0.9 | 0.5-1.5 | .80 |
| Gene . | Genotype . | OR . | 95% CI . | P . |
|---|---|---|---|---|
| CYP1A13-151 | *2A | 1.8 | 1.1-3.1 | .033-155 |
| *2B | 0.9 | 0.4-1.8 | .90 | |
| *4 | 0.6 | 0.3-1.2 | .16 | |
| CYP2D63-152 | *3 | 5.5 | 0.6-53.4 | .13 |
| *4 | 1.6 | 0.6-4.1 | .40 | |
| PM | 1.8 | 0.8-4.4 | .17 | |
| GSTM13-153 | Null | 1.8 | 1.2-2.6 | .0043-155 |
| GSTT13-153 | Null | 0.9 | 0.5-1.5 | .80 |
Abbreviations: OR, crude odds ratio; CI, confidence interval.
Heterozygous and homozygous mutant combined.
Homozygous mutant only; PM, poor metabolizer, ie, homozygous and combined heterozygous for mutant alleles.
Null, homozygous deletion.
The use of the Bonferroni correction (k = 8) for multiple testing did not change the interpretation of the result for GSTM1 null genotype.