Clinical and Biological Status of 17 Patients With EBV-HLH
| Sex | 4M, 13F |
| Median age (range) at diagnosis | 4 yr (0.8-12.3) |
| Family history of HLH | None |
| Initial clinical presentation (no. of cases) | |
| Persistent fever (≥38.5°C) | 17 |
| Hepatosplenomegaly | 15 |
| Coagulopathy | 13 |
| CNS symptoms | 3 |
| Lymphadenopathy | 10 |
| Jaundice | 9 |
| Pleural effusion | 6 |
| Initial biological presentation (no. of cases)* | |
| Cytopenia | 17 |
| Hypertriglyceridemia | 12 |
| Hypofibrinogenemia | 13 |
| Serum ferritin >1,000 ng/mL | 12 |
| Serum LDH >1,000 IU/L | 16 |
| Specimen positive for EBV-DNA | 17 |
| Sex | 4M, 13F |
| Median age (range) at diagnosis | 4 yr (0.8-12.3) |
| Family history of HLH | None |
| Initial clinical presentation (no. of cases) | |
| Persistent fever (≥38.5°C) | 17 |
| Hepatosplenomegaly | 15 |
| Coagulopathy | 13 |
| CNS symptoms | 3 |
| Lymphadenopathy | 10 |
| Jaundice | 9 |
| Pleural effusion | 6 |
| Initial biological presentation (no. of cases)* | |
| Cytopenia | 17 |
| Hypertriglyceridemia | 12 |
| Hypofibrinogenemia | 13 |
| Serum ferritin >1,000 ng/mL | 12 |
| Serum LDH >1,000 IU/L | 16 |
| Specimen positive for EBV-DNA | 17 |
Abbreviations: EBV-HLH, Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis; LDH, lactate dehydrogenase.
Normal laboratory values are reported in the text.