Body and Organ Weights of Transfused Mice
| . | Body Weight (g) . | Spleen (g) . | Liver (g) . | Kidneys (g) . | Heart (g) . | |
|---|---|---|---|---|---|---|
| Initial . | Final . | |||||
| Saline transfused | 19.9 ± 0.9 | 26.1 ± 1.4 | 0.12 ± 0.01 | 1.56 ± 0.18 | 0.50 ± 0.06 | 0.18 ± 0.02 |
| Control RBC | 19.9 ± 1.1 | 25.7 ± 0.6 | 0.17 ± 0.05* | 1.55 ± 0.03 | 0.55 ± 0.04 | 0.19 ± 0.02 |
| PEG-RBC | 20.1 ± 1.1 | 25.7 ± 0.9 | 0.14 ± 0.02 | 1.59 ± 0.16 | 0.51 ± 0.05 | 0.20 ± 0.01 |
| . | Body Weight (g) . | Spleen (g) . | Liver (g) . | Kidneys (g) . | Heart (g) . | |
|---|---|---|---|---|---|---|
| Initial . | Final . | |||||
| Saline transfused | 19.9 ± 0.9 | 26.1 ± 1.4 | 0.12 ± 0.01 | 1.56 ± 0.18 | 0.50 ± 0.06 | 0.18 ± 0.02 |
| Control RBC | 19.9 ± 1.1 | 25.7 ± 0.6 | 0.17 ± 0.05* | 1.55 ± 0.03 | 0.55 ± 0.04 | 0.19 ± 0.02 |
| PEG-RBC | 20.1 ± 1.1 | 25.7 ± 0.9 | 0.14 ± 0.02 | 1.59 ± 0.16 | 0.51 ± 0.05 | 0.20 ± 0.01 |
Mice were transfused as described in the Materials and Methods with syngeneic murine RBC derivatized with 0.4 mmol/L mPEG. Mice received a total of 33 transfusions (400 μL each of a 40% hematocrit) of control or mPEG-modified RBC (N = 6 mice/group).
P < .05 in comparison to saline injected animals.