Effect of Ibandronate on Tumor Burden to the Liver and Spleen in 5TGM1 Myeloma-Bearing Mice
| Treatment Group . | Organ Weights (g) . | Percent Tumor Volume . | ||
|---|---|---|---|---|
| Spleen . | Liver . | Spleen . | Liver . | |
| Control + PBS (n = 6) | 0.066 ± 0.003 | 1.029 ± 0.051 | None | None |
| Control + IBN (n = 6) | 0.073 ± 0.006 | 1.060 ± 0.020 | None | None |
| Myeloma + PBS (n = 6) | 0.191 ± 0.027* | 1.778 ± 0.089* | 47.0 ± 9.40* | 2.58 ± 0.66* |
| Myeloma + IBN (n = 6) | 0.194 ± 0.015* | 1.246 ± 0.029 | 59.4 ± 5.23* | 3.29 ± 1.22* |
| Treatment Group . | Organ Weights (g) . | Percent Tumor Volume . | ||
|---|---|---|---|---|
| Spleen . | Liver . | Spleen . | Liver . | |
| Control + PBS (n = 6) | 0.066 ± 0.003 | 1.029 ± 0.051 | None | None |
| Control + IBN (n = 6) | 0.073 ± 0.006 | 1.060 ± 0.020 | None | None |
| Myeloma + PBS (n = 6) | 0.191 ± 0.027* | 1.778 ± 0.089* | 47.0 ± 9.40* | 2.58 ± 0.66* |
| Myeloma + IBN (n = 6) | 0.194 ± 0.015* | 1.246 ± 0.029 | 59.4 ± 5.23* | 3.29 ± 1.22* |
The effect of ibandronate treatment (4 μg per mouse per day for 28 days) on tumor burden to liver and spleen, as assessed by organ weights and percent tumor volume as measured by histomorphometry. Data are mean ± SEM.
Significantly different from control + PBS.