Clinicopathologic Findings in Correlation With Cytogenetics in 42 MCL
| . | +12 . | 13q− . | 17p− . | Cytogenetic Groups . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Yes n = 12 . | No n = 30 . | Yes n = 22 . | No n = 20 . | Yes n = 11 . | No n = 31 . | 1 n = 11 . | 2 n = 14 . | 3 n = 17 . | |
| Male | 11 | 18 | 17 | 12 | 6 | 23 | 4 | 10 | 15 |
| Female | 1 | 12 | 5 | 8 | 5 | 8 | 7 | 4 | 2 |
| P = .045 | P = .227 | P = .226 | P = .015 | ||||||
| Stage | |||||||||
| Advanced | 10 | 21 | 17 | 14 | 9 | 22 | 6 | 11 | 14 |
| Initial | 2 | 9 | 5 | 6 | 2 | 9 | 5 | 3 | 3 |
| P = .375 | P = .592 | P = .482 | P = .232 | ||||||
| PS 0-1 | 11 | 25 | 19 | 17 | 9 | 27 | 11 | 12 | 13 |
| PS 2-4 | 1 | 5 | 3 | 3 | 2 | 4 | 0 | 2 | 4 |
| P = .486 | P = .90 | P = .667 | P = .221 | ||||||
| Splenomegaly | |||||||||
| Yes | 6 | 13 | 13 | 6 | 6 | 13 | 3 | 8 | 8 |
| No | 6 | 17 | 9 | 14 | 5 | 18 | 8 | 6 | 9 |
| P = .695 | P = .059 | P = .470 | P = .324 | ||||||
| Albumin | |||||||||
| <4.0 gr/dl | 6 | 23 | 13 | 16 | 6 | 23 | 7 | 11 | 11 |
| >4.0 gr/dl | 5 | 7 | 9 | 4 | 5 | 8 | 4 | 3 | 6 |
| P = .091 | P = .143 | P = .226 | P = .639 | ||||||
| BM involved | 6 | 21 | 16 | 11 | 5 | 22 | 8 | 11 | 8 |
| BM not involved | 6 | 9 | 6 | 9 | 6 | 9 | 3 | 3 | 9 |
| P = .222 | P = .231 | P = .129 | P = .151 | ||||||
| PB involved | 9 | 22 | 17 | 14 | 7 | 24 | 8 | 9 | 14 |
| PB not involved | 3 | 8 | 5 | 6 | 4 | 7 | 3 | 5 | 3 |
| P = .912 | P = .592 | P = .372 | P = .521 | ||||||
| Age <60 | 3 | 10 | 8 | 5 | 4 | 9 | 2 | 4 | 7 |
| Age >60 | 9 | 20 | 14 | 15 | 7 | 22 | 9 | 10 | 10 |
| P = .598 | P = .426 | P = .426 | P = .426 | ||||||
| LDH normal | 6 | 17 | 11 | 12 | 4 | 19 | 8 | 8 | 7 |
| LDH elevated | 6 | 12 | 11 | 7 | 7 | 11 | 2 | 6 | 10 |
| P = .613 | P = .397 | P = .123 | P = .145 | ||||||
| Extranodal disease | |||||||||
| No | 3 | 11 | 8 | 6 | 3 | 11 | 6 | 4 | 4 |
| Yes | 9 | 19 | 14 | 14 | 8 | 20 | 5 | 10 | 13 |
| P = .469 | P = .662 | P = .142 | P = .212 | ||||||
| . | +12 . | 13q− . | 17p− . | Cytogenetic Groups . | |||||
|---|---|---|---|---|---|---|---|---|---|
| Yes n = 12 . | No n = 30 . | Yes n = 22 . | No n = 20 . | Yes n = 11 . | No n = 31 . | 1 n = 11 . | 2 n = 14 . | 3 n = 17 . | |
| Male | 11 | 18 | 17 | 12 | 6 | 23 | 4 | 10 | 15 |
| Female | 1 | 12 | 5 | 8 | 5 | 8 | 7 | 4 | 2 |
| P = .045 | P = .227 | P = .226 | P = .015 | ||||||
| Stage | |||||||||
| Advanced | 10 | 21 | 17 | 14 | 9 | 22 | 6 | 11 | 14 |
| Initial | 2 | 9 | 5 | 6 | 2 | 9 | 5 | 3 | 3 |
| P = .375 | P = .592 | P = .482 | P = .232 | ||||||
| PS 0-1 | 11 | 25 | 19 | 17 | 9 | 27 | 11 | 12 | 13 |
| PS 2-4 | 1 | 5 | 3 | 3 | 2 | 4 | 0 | 2 | 4 |
| P = .486 | P = .90 | P = .667 | P = .221 | ||||||
| Splenomegaly | |||||||||
| Yes | 6 | 13 | 13 | 6 | 6 | 13 | 3 | 8 | 8 |
| No | 6 | 17 | 9 | 14 | 5 | 18 | 8 | 6 | 9 |
| P = .695 | P = .059 | P = .470 | P = .324 | ||||||
| Albumin | |||||||||
| <4.0 gr/dl | 6 | 23 | 13 | 16 | 6 | 23 | 7 | 11 | 11 |
| >4.0 gr/dl | 5 | 7 | 9 | 4 | 5 | 8 | 4 | 3 | 6 |
| P = .091 | P = .143 | P = .226 | P = .639 | ||||||
| BM involved | 6 | 21 | 16 | 11 | 5 | 22 | 8 | 11 | 8 |
| BM not involved | 6 | 9 | 6 | 9 | 6 | 9 | 3 | 3 | 9 |
| P = .222 | P = .231 | P = .129 | P = .151 | ||||||
| PB involved | 9 | 22 | 17 | 14 | 7 | 24 | 8 | 9 | 14 |
| PB not involved | 3 | 8 | 5 | 6 | 4 | 7 | 3 | 5 | 3 |
| P = .912 | P = .592 | P = .372 | P = .521 | ||||||
| Age <60 | 3 | 10 | 8 | 5 | 4 | 9 | 2 | 4 | 7 |
| Age >60 | 9 | 20 | 14 | 15 | 7 | 22 | 9 | 10 | 10 |
| P = .598 | P = .426 | P = .426 | P = .426 | ||||||
| LDH normal | 6 | 17 | 11 | 12 | 4 | 19 | 8 | 8 | 7 |
| LDH elevated | 6 | 12 | 11 | 7 | 7 | 11 | 2 | 6 | 10 |
| P = .613 | P = .397 | P = .123 | P = .145 | ||||||
| Extranodal disease | |||||||||
| No | 3 | 11 | 8 | 6 | 3 | 11 | 6 | 4 | 4 |
| Yes | 9 | 19 | 14 | 14 | 8 | 20 | 5 | 10 | 13 |
| P = .469 | P = .662 | P = .142 | P = .212 | ||||||