Sensitivity of AML Primary Cultures to Lovastatin-Induced Cytotoxicity
| Patient . | UPN . | Source of Cells . | Age (yr)/ Sex . | WBC Count (×109/L) . | Blast Count (×109/L) . | FAB . | MTT 50 μmol/L Lovastatin . | MTT 30 μmol/L Lovastatin . |
|---|---|---|---|---|---|---|---|---|
| Nonresponsive | ||||||||
| A | 1054 | Cryo | 48/M | 71.3 | 10.0 | M4 | >150 | >150 |
| B | 1270 | Fresh | 60/F | 9.3 | 6.1 | M4 | 148 | >150 |
| Weak | ||||||||
| C | 683 | Cryo | 48/M | 97.0 | 34.9 | M4 | 26 | 106 |
| D | 1350 | Fresh | 73/M | 11.7 | 6.7 | M1 | 63 | 105 |
| E | 733 | Cryo | 65/M | 95.0 | 14.3 | M4 | 105 | 145 |
| F | 881 | Fresh | 59/F | 234.0 | 63.2 | M4 | 69 | 150 |
| G | 870 | Cryo | 38/F | 42.5 | 36.5 | M3 | 61 | >150 |
| H | 1475 | Fresh | 45/F | 6.7 | ND | M2 | 38 | >150 |
| I | 1333 | Fresh | 19/M | 99.6 | 44.9 | M2 | 69 | 103 |
| Sensitive | ||||||||
| J | 473 | Fresh | 36/F | 25.7 | 5.1 | M2 | 15 | 44 |
| K | 355 | Cryo | 70/F | 44.0 | 37.0 | M2 | 14 | 26 |
| L | 1234 | Fresh | 70/F | 37.0 | 5.0 | M4 | 32 | 62 |
| M | 1083 | Fresh | 81/M | 20.4 | 17.0 | M1 | 39 | 64 |
| N | 1352 | Fresh | 65/F | 8.1 | 4.9 | M2 | 9 | 90 |
| O | 841 | Cryo | 32/M | 143.5 | 140.6 | M4 | 3 | 6 |
| P | 328 | Cryo | 16/F | 301.0 | 273.9 | M4 | 20 | 56 |
| Q | 1373 | Fresh | 75/F | 146.0 | 93.7 | M4 | 8 | 20 |
| R | 805 | Cryo | 71/F | 51.6 | 35.1 | M5 | 22 | 84 |
| S | 1344 | Fresh | 45/F | 41.7 | 37.7 | M2 | 16 | 33 |
| T | 1119 | Cryo | 71/M | 208.5 | 204.3 | M1 | 8 | 27 |
| U | 1316 | Fresh | 36/M | 5.6 | 2.2 | M5a | 6 | 50 |
| V | 913 | Fresh | 48/F | 12.2 | 7.4 | M2 | 7 | 15 |
| Patient . | UPN . | Source of Cells . | Age (yr)/ Sex . | WBC Count (×109/L) . | Blast Count (×109/L) . | FAB . | MTT 50 μmol/L Lovastatin . | MTT 30 μmol/L Lovastatin . |
|---|---|---|---|---|---|---|---|---|
| Nonresponsive | ||||||||
| A | 1054 | Cryo | 48/M | 71.3 | 10.0 | M4 | >150 | >150 |
| B | 1270 | Fresh | 60/F | 9.3 | 6.1 | M4 | 148 | >150 |
| Weak | ||||||||
| C | 683 | Cryo | 48/M | 97.0 | 34.9 | M4 | 26 | 106 |
| D | 1350 | Fresh | 73/M | 11.7 | 6.7 | M1 | 63 | 105 |
| E | 733 | Cryo | 65/M | 95.0 | 14.3 | M4 | 105 | 145 |
| F | 881 | Fresh | 59/F | 234.0 | 63.2 | M4 | 69 | 150 |
| G | 870 | Cryo | 38/F | 42.5 | 36.5 | M3 | 61 | >150 |
| H | 1475 | Fresh | 45/F | 6.7 | ND | M2 | 38 | >150 |
| I | 1333 | Fresh | 19/M | 99.6 | 44.9 | M2 | 69 | 103 |
| Sensitive | ||||||||
| J | 473 | Fresh | 36/F | 25.7 | 5.1 | M2 | 15 | 44 |
| K | 355 | Cryo | 70/F | 44.0 | 37.0 | M2 | 14 | 26 |
| L | 1234 | Fresh | 70/F | 37.0 | 5.0 | M4 | 32 | 62 |
| M | 1083 | Fresh | 81/M | 20.4 | 17.0 | M1 | 39 | 64 |
| N | 1352 | Fresh | 65/F | 8.1 | 4.9 | M2 | 9 | 90 |
| O | 841 | Cryo | 32/M | 143.5 | 140.6 | M4 | 3 | 6 |
| P | 328 | Cryo | 16/F | 301.0 | 273.9 | M4 | 20 | 56 |
| Q | 1373 | Fresh | 75/F | 146.0 | 93.7 | M4 | 8 | 20 |
| R | 805 | Cryo | 71/F | 51.6 | 35.1 | M5 | 22 | 84 |
| S | 1344 | Fresh | 45/F | 41.7 | 37.7 | M2 | 16 | 33 |
| T | 1119 | Cryo | 71/M | 208.5 | 204.3 | M1 | 8 | 27 |
| U | 1316 | Fresh | 36/M | 5.6 | 2.2 | M5a | 6 | 50 |
| V | 913 | Fresh | 48/F | 12.2 | 7.4 | M2 | 7 | 15 |
Age, WBC, and blast counts in peripheral blood at registration.
Abbreviations: UPN, unique patient number; Cryo, cryopreserved; WBC, white blood cell; ND, not detected.