Clinical, Histological, Clonal and Immunological Features of Lymphoma and sAIDS in SIV-Infected Monkeys
| Animal No. . | DPI . | Diagnosis . | Histology . | Clonality . | %CD4 (day 0/ autopsy) . | Rate* . |
|---|---|---|---|---|---|---|
| 1 | 209 | Lymphoma | DLC | monoclonal | 47/8 | −0.1866 |
| 2 | 283 | Lymphoma | DLC | monoclonal | 25/1 | −0.0848 |
| 3 | 371 | Lymphoma | DLC | oligoclonal | 42/8 | −0.0916 |
| 4 | 397 | Lymphoma | DLC | monoclonal | 27/22 | −0.0126 |
| 5 | 450 | Lymphoma | DLC | not done | 31/26 | −0.0111 |
| 6 | 539 | Lymphoma | DLC | oligoclonal | 36/7 | −0.0538 |
| 7 | 547 | Lymphoma | DLC | monoclonal | 32/6 | −0.0475 |
| 8 | 569 | Lymphoma | DLC | monoclonal | 19/9 | −0.0176 |
| 9 | 696 | Lymphoma | DLC | monoclonal | 39/1 | −0.0546 |
| 10 | 856 | Lymphoma | DLC | monoclonal | 36/8 | −0.0327 |
| 11 | 1159 | sAIDS | 40/14 | −0.0224 | ||
| 12 | 679 | sAIDS | 39/1 | −0.0559 | ||
| 13 | 810 | sAIDS | 34/16 | −0.0222 | ||
| 14 | 720 | sAIDS | 26/1 | −0.0347 | ||
| 15 | 630 | sAIDS | 26/7 | −0.0302 | ||
| 16 | 450 | sAIDS | 32/1 | −0.0689 | ||
| 17 | 450 | sAIDS | 44/11 | −0.0733 | ||
| 18 | 450 | sAIDS | 34/12 | −0.0489 | ||
| 19 | 450 | sAIDS | 35/11 | −0.0533 | ||
| 20 | 360 | sAIDS | 40/1 | −0.1083 | ||
| 21 | 360 | sAIDS | 25/15 | −0.0278 | ||
| 22 | 60 | sAIDS | 25/23 | −0.0333 |
| Animal No. . | DPI . | Diagnosis . | Histology . | Clonality . | %CD4 (day 0/ autopsy) . | Rate* . |
|---|---|---|---|---|---|---|
| 1 | 209 | Lymphoma | DLC | monoclonal | 47/8 | −0.1866 |
| 2 | 283 | Lymphoma | DLC | monoclonal | 25/1 | −0.0848 |
| 3 | 371 | Lymphoma | DLC | oligoclonal | 42/8 | −0.0916 |
| 4 | 397 | Lymphoma | DLC | monoclonal | 27/22 | −0.0126 |
| 5 | 450 | Lymphoma | DLC | not done | 31/26 | −0.0111 |
| 6 | 539 | Lymphoma | DLC | oligoclonal | 36/7 | −0.0538 |
| 7 | 547 | Lymphoma | DLC | monoclonal | 32/6 | −0.0475 |
| 8 | 569 | Lymphoma | DLC | monoclonal | 19/9 | −0.0176 |
| 9 | 696 | Lymphoma | DLC | monoclonal | 39/1 | −0.0546 |
| 10 | 856 | Lymphoma | DLC | monoclonal | 36/8 | −0.0327 |
| 11 | 1159 | sAIDS | 40/14 | −0.0224 | ||
| 12 | 679 | sAIDS | 39/1 | −0.0559 | ||
| 13 | 810 | sAIDS | 34/16 | −0.0222 | ||
| 14 | 720 | sAIDS | 26/1 | −0.0347 | ||
| 15 | 630 | sAIDS | 26/7 | −0.0302 | ||
| 16 | 450 | sAIDS | 32/1 | −0.0689 | ||
| 17 | 450 | sAIDS | 44/11 | −0.0733 | ||
| 18 | 450 | sAIDS | 34/12 | −0.0489 | ||
| 19 | 450 | sAIDS | 35/11 | −0.0533 | ||
| 20 | 360 | sAIDS | 40/1 | −0.1083 | ||
| 21 | 360 | sAIDS | 25/15 | −0.0278 | ||
| 22 | 60 | sAIDS | 25/23 | −0.0333 |
In monkeys 13-22, DPI were estimated as months postinfection ×30.
Abbreviations: DPI, Days postinfection; sAIDS, simian AIDS; DLC, Diffuse large cell lymphoma; %CD4, %CD4 at day 0/last test before autopsy; Rate*, Rate of CD4 positive cells decline = [(%CD4 at autopsy) − (%CD4 at day 0)]/Days postinfection.