Table 1. Inhibition of Complement... | American Society of Hematology

Table 1.

Inhibition of Complement Deposition on Aggregated Rabbit IgG by Different IVIG Preparations

	Complement Component
	C1q	C4	C3
IVIgM
25 mg/mL	84^*	92	70
1 mg/mL	52	87	53
Pentaglobin
25 mg/mL	83	93	74
1 mg/mL	42	79	64
IVIgG
25 mg/mL	52	86	56
1 mg/mL	15	4	1
IVIgA
25 mg/mL	0	0	0
1 mg/mL	10	0	0

	Complement Component
	C1q	C4	C3
IVIgM
25 mg/mL	84^*	92	70
1 mg/mL	52	87	53
Pentaglobin
25 mg/mL	83	93	74
1 mg/mL	42	79	64
IVIgG
25 mg/mL	52	86	56
1 mg/mL	15	4	1
IVIgA
25 mg/mL	0	0	0
1 mg/mL	10	0	0

Human serum, diluted 1:200 in GVB⁺⁺, was incubated on a plate coated with rabbit aIgG together with a serial dilution of the different IVIG preparations. After the incubation, deposition of C1q, C4, and C3 on the aIgG were measured by ELISA. The values given are the percentages of inhibition of complement deposition that were reached with 1 and 25 mg/mL of IVIG, respectively.

Percent inhibition.

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