Table 4. Predictive Value of CCR2, CCR5,... | American Society of Hematology

Table 4.

Predictive Value of CCR2, CCR5, and SDF1 Alleles and HLA Genotypes for the LT-NP Status

			ALT (LT-NPs) N = 70	IMMUNOCO (progressors) N = 83	Multivariate Odds-ratio^4-150	Overall P Value
CCR2	CCR5	SDF1				.003
Wild^4-151	Wild	Wild	18	38	1
Wild	Wild	Mut	13	21	1.2 [0.4-3.3]
Mut	Wild	Wild	8	6	4.6 [1.1-19.5]
Mut	Wild	Mut	5	6	2.7 [0.6-11.8]
Wild or mut	Mut	Wild	19	3	25.8 [4.7-141.1]
Wild or mut	Mut	Mut	7	9	3.4 [0.9-13.7]
B27	DR6					.001
Absent	Absent		38	66	1
Absent	Present		18	14	3.9 [1.5-10]
Present	Absent		11	1	51.0 [4.9-526.8]
Present	Present		3	2	5.1 [0.5-55.3]
HLA score^‡						.001
0 marker			14	37	1
1 or 2 markers			49	45	4.7 [1.7-12.6]
3 or 4 markers			7	1	49.5 [4.5-541.7]

			ALT (LT-NPs) N = 70	IMMUNOCO (progressors) N = 83	Multivariate Odds-ratio^4-150	Overall P Value
CCR2	CCR5	SDF1				.003
Wild^4-151	Wild	Wild	18	38	1
Wild	Wild	Mut	13	21	1.2 [0.4-3.3]
Mut	Wild	Wild	8	6	4.6 [1.1-19.5]
Mut	Wild	Mut	5	6	2.7 [0.6-11.8]
Wild or mut	Mut	Wild	19	3	25.8 [4.7-141.1]
Wild or mut	Mut	Mut	7	9	3.4 [0.9-13.7]
B27	DR6					.001
Absent	Absent		38	66	1
Absent	Present		18	14	3.9 [1.5-10]
Present	Absent		11	1	51.0 [4.9-526.8]
Present	Present		3	2	5.1 [0.5-55.3]
HLA score^‡						.001
0 marker			14	37	1
1 or 2 markers			49	45	4.7 [1.7-12.6]
3 or 4 markers			7	1	49.5 [4.5-541.7]

The values in brackets represent the 95% confidence interval; odds-ratio are statistically significant if the CI95% values are above 1.0.

Wild stands for wild/wild genotypes and mut stands for wild/mut (CCR5, CCR2, SDF1) or mut/mut (CCR2 and SDF1) genotypes.

HLA score was constructed with the following markers: HLA-A3, HLA-B14, HLA-B17, and HLA-DR7.