The Frequency of CCR5, CCR2, SDF1, and HLA Genotypes in LT-NP and Progressors
| Gene or Genotype . | ALT (LT-NPs) n = 70 (%) . | IMMUNOCO (progressors) n = 83 (%) . | P Value . |
|---|---|---|---|
| CCR5 | |||
| Wild/mut* | 26 (37) | 9 (11) | .001 |
| CCR2 | |||
| Wild/mut | 14 (20) | 13 (16) | .221 |
| Mut/mut | 2 (3) | 0 | |
| SDF1 | |||
| Wild/mut | 23 (33) | 32 (39) | .581 |
| Mut/mut | 2 (3) | 4 (5) | |
| HLA-A3 | 22 (31) | 13 (16) | .021 |
| HLA-B12 | 13 (19) | 27 (33) | .050 |
| HLA-B14 | 14 (20) | 9 (11) | .114 |
| HLA-B17 | 19 (27) | 11 (13) | .031 |
| HLA-B27 | 14 (20) | 3 (4) | .001 |
| HLA-DR6 | 21 (30) | 16 (19) | .123 |
| HLA-DR7 | 28 (40) | 24 (29) | .149 |
| Gene or Genotype . | ALT (LT-NPs) n = 70 (%) . | IMMUNOCO (progressors) n = 83 (%) . | P Value . |
|---|---|---|---|
| CCR5 | |||
| Wild/mut* | 26 (37) | 9 (11) | .001 |
| CCR2 | |||
| Wild/mut | 14 (20) | 13 (16) | .221 |
| Mut/mut | 2 (3) | 0 | |
| SDF1 | |||
| Wild/mut | 23 (33) | 32 (39) | .581 |
| Mut/mut | 2 (3) | 4 (5) | |
| HLA-A3 | 22 (31) | 13 (16) | .021 |
| HLA-B12 | 13 (19) | 27 (33) | .050 |
| HLA-B14 | 14 (20) | 9 (11) | .114 |
| HLA-B17 | 19 (27) | 11 (13) | .031 |
| HLA-B27 | 14 (20) | 3 (4) | .001 |
| HLA-DR6 | 21 (30) | 16 (19) | .123 |
| HLA-DR7 | 28 (40) | 24 (29) | .149 |
To simplify the presentation of results, we substituted the mutation symbols −Δ32, 64I and 3′A, by mut. Thus, the heterozygous genotype was noted as wild/mut and the homozygous genotypes were noted as wild/wild and mut/mut for each of the three screened genes.