Table 1.

Diagnostic Criteria: Essential Thrombocythemia

I.  Platelet count >600,000/μL 
II.  Hematocrit <40, or normal RBC mass (males <36 mL/kg, females <32 mL/kg) 
III.  Stainable iron in marrow or normal serum ferritin or normal RBC mean corpuscular volume* 
IV.  No Philadelphia chromosome or bcr/abl gene rearrangement 
V.  Collagen fibrosis of marrow 
 A. Absent or 
 B.  <13 of biopsy involved and neither marked splenomegaly nor a leukoerythroblastic reaction 
VI.  No cytogenetic or morphologic evidence for a myelodysplastic syndrome 
VII. No cause for reactive thrombocytosis 
I.  Platelet count >600,000/μL 
II.  Hematocrit <40, or normal RBC mass (males <36 mL/kg, females <32 mL/kg) 
III.  Stainable iron in marrow or normal serum ferritin or normal RBC mean corpuscular volume* 
IV.  No Philadelphia chromosome or bcr/abl gene rearrangement 
V.  Collagen fibrosis of marrow 
 A. Absent or 
 B.  <13 of biopsy involved and neither marked splenomegaly nor a leukoerythroblastic reaction 
VI.  No cytogenetic or morphologic evidence for a myelodysplastic syndrome 
VII. No cause for reactive thrombocytosis 
*

If these measurements suggest iron deficiency, PV cannot be excluded unless a trial of iron therapy fails to increase the RBC mass into the polycythemic range.

Modified and reprinted with permission.12 

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