DNA Typing of Patients and URD Who Were Homozygous by Serology at HLA-A or HLA-B Loci
| . | HLA-A . | . | HLA-B . | ||||
|---|---|---|---|---|---|---|---|
| Serotype . | Subjects With One Blank Antigen (Phenotypic Homozygous) . | Subjects With One Blank Allele (Genotypic Homozygous) . | Serotype . | Subjects With One Blank Antigen (Phenotypic Homozygous) . | Subjects With One Blank Allele (Genotypic Homozygous) . | ||
| A2 | 11# | 6 | B18 | 1 | 1 | ||
| A3 | 2 | 2 | Patients | B35 | 47-153 | 1 | |
| Patients | A11 | 1 | 0 | B51 | 1 | 0 | |
| A24 | 2 | 2 | B58 | 1 | 1 | ||
| A29 | 1 | 0 | Total | 7 | 3 | ||
| A34 | 1 | 0 | |||||
| Total | 18 | 10 | B7 | 1 | 1 | ||
| B18 | 67-155 | 6 | |||||
| A1 | 2 | 2 | B35 | 327-154 | 6 | ||
| A2 | 507-151 | 33 | B45 | 1 | 0 | ||
| A3 | 57-152 | 4 | B49 | 1 | 0 | ||
| A11 | 4 | 3 | URD | B5 | 1 | 1 | |
| URD | A23 | 1 | 0 | B51 | 1 | 0 | |
| A24 | 2 | 2 | B53 | 2 | 2 | ||
| A29 | 1 | 0 | B58 | 1 | 0 | ||
| A30 | 1 | 0 | B61 | 1 | 1 | ||
| A33 | 1 | 0 | B70 | 1 | 0 | ||
| Total | 68 | 44 | Total | 48 | 17 | ||
| . | HLA-A . | . | HLA-B . | ||||
|---|---|---|---|---|---|---|---|
| Serotype . | Subjects With One Blank Antigen (Phenotypic Homozygous) . | Subjects With One Blank Allele (Genotypic Homozygous) . | Serotype . | Subjects With One Blank Antigen (Phenotypic Homozygous) . | Subjects With One Blank Allele (Genotypic Homozygous) . | ||
| A2 | 11# | 6 | B18 | 1 | 1 | ||
| A3 | 2 | 2 | Patients | B35 | 47-153 | 1 | |
| Patients | A11 | 1 | 0 | B51 | 1 | 0 | |
| A24 | 2 | 2 | B58 | 1 | 1 | ||
| A29 | 1 | 0 | Total | 7 | 3 | ||
| A34 | 1 | 0 | |||||
| Total | 18 | 10 | B7 | 1 | 1 | ||
| B18 | 67-155 | 6 | |||||
| A1 | 2 | 2 | B35 | 327-154 | 6 | ||
| A2 | 507-151 | 33 | B45 | 1 | 0 | ||
| A3 | 57-152 | 4 | B49 | 1 | 0 | ||
| A11 | 4 | 3 | URD | B5 | 1 | 1 | |
| URD | A23 | 1 | 0 | B51 | 1 | 0 | |
| A24 | 2 | 2 | B53 | 2 | 2 | ||
| A29 | 1 | 0 | B58 | 1 | 0 | ||
| A30 | 1 | 0 | B61 | 1 | 1 | ||
| A33 | 1 | 0 | B70 | 1 | 0 | ||
| Total | 68 | 44 | Total | 48 | 17 | ||
Following the DNA typing many serologically homozygous individuals were found to be genotypically heterozygous. A marked difference is evident between HLA-A and -B loci as well as between various serotypes. Symbols represent the frequency of various allelic combinations within the marked homozygous serotype.
#(A*0201/A*0201-6; A*0201/A*0202-1; A*0201/A*0205-1; A*0201/A*0206-1; A*0201/A02∧-1; A02∧/A02∧-1).
(A*0201/A*0201-27; A*0201/A*0202-2; A*0201/A*0205-1; A*0201/A02∧-15; A02∧/A02∧-2; A*0201/A*3201-1; A*0201/A*6802-1; A*0201/ A*7401-1).
(A*0301/A*0301-4; A*0301/A03∧-1).
(B*3501/B*3501-1; B*3501/B*3502-1; B*3501/B*3508-1; B*3501/B*3509V-1).
(B*1801/B*1801-6).
(B*3501/B*3501-5; B*3508/B*3508-1; B*3501/B*3502-17; B*3501/B*3503-1; B*3501/B*3504-1; B*3501/B*3505-1; B*3501/B*3508-1; B*3501/B*1522-1; B*3501/B*35∧-1; B*3503/B3508-1; B*3503/B*5401-1; B*3504/B*3505-1).