Effects of G-CSF on Bacterial Products, Cytokines, and Survival Administered Before Induction of Sepsis in Animals
Animal . | Sepsis Model . | Effects of G-CSF on . | Reference . | ||||
---|---|---|---|---|---|---|---|
Endotoxin Levels . | Bacterial Counts . | TNF-α . | Interleukins . | Survival . | |||
Mouse/rat | LPS-induced septic shock | ↓ | ↑ | 108 | |||
Canine | Intraperitoneal E coli clot | ↓ | ↓ | ↓ | ↑ | 141 | |
Rat | Fecal inoculum | ↓ | ↑ | 142 | |||
Porcine | Pseudomonas sepsis | ↓ | ↓ | ↑ | 143 | ||
Rat | Cecal perforation | ↓ | ↓ | ↓ | ↑ | 105 | |
Mouse | Superantigen mediated shock | ↓ IL-2 | ↑ | 140 | |||
Mouse | LPS-induced septic shock | — | ↓ IL-1β | ↑ | 144 | ||
↓ IFN-γ | |||||||
↓ IL-10 |
Animal . | Sepsis Model . | Effects of G-CSF on . | Reference . | ||||
---|---|---|---|---|---|---|---|
Endotoxin Levels . | Bacterial Counts . | TNF-α . | Interleukins . | Survival . | |||
Mouse/rat | LPS-induced septic shock | ↓ | ↑ | 108 | |||
Canine | Intraperitoneal E coli clot | ↓ | ↓ | ↓ | ↑ | 141 | |
Rat | Fecal inoculum | ↓ | ↑ | 142 | |||
Porcine | Pseudomonas sepsis | ↓ | ↓ | ↑ | 143 | ||
Rat | Cecal perforation | ↓ | ↓ | ↓ | ↑ | 105 | |
Mouse | Superantigen mediated shock | ↓ IL-2 | ↑ | 140 | |||
Mouse | LPS-induced septic shock | — | ↓ IL-1β | ↑ | 144 | ||
↓ IFN-γ | |||||||
↓ IL-10 |
Abbreviations: ↑, increase; −, no effect; ↓, decrease.