Table 3.

Effects of G-CSF on Bacterial Products, Cytokines, and Survival Administered Before Induction of Sepsis in Animals

Animal Sepsis ModelEffects of G-CSF on Reference
Endotoxin Levels Bacterial Counts TNF-αInterleukins Survival
Mouse/rat  LPS-induced septic shock    ↓   ↑  108  
Canine Intraperitoneal E coli clot  ↓  ↓  ↓  ↑  141  
Rat  Fecal inoculum    ↓  ↑  142  
Porcine  Pseudomonas sepsis  ↓  ↓   ↑  143  
Rat  Cecal perforation  ↓ ↓  ↓   ↑  105  
Mouse  Superantigen mediated shock     ↓ IL-2  ↑  140  
Mouse LPS-induced septic shock    —  ↓ IL-1β  ↑ 144  
     ↓ IFN-γ 
     ↓ IL-10 
Animal Sepsis ModelEffects of G-CSF on Reference
Endotoxin Levels Bacterial Counts TNF-αInterleukins Survival
Mouse/rat  LPS-induced septic shock    ↓   ↑  108  
Canine Intraperitoneal E coli clot  ↓  ↓  ↓  ↑  141  
Rat  Fecal inoculum    ↓  ↑  142  
Porcine  Pseudomonas sepsis  ↓  ↓   ↑  143  
Rat  Cecal perforation  ↓ ↓  ↓   ↑  105  
Mouse  Superantigen mediated shock     ↓ IL-2  ↑  140  
Mouse LPS-induced septic shock    —  ↓ IL-1β  ↑ 144  
     ↓ IFN-γ 
     ↓ IL-10 

Abbreviations: ↑, increase; −, no effect; ↓, decrease.

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