Tumor Growth of EL4 Cells Infected Ex Vivo With HSV Amplicons
| HSV Amplicon . | No. of Mice With Tumor/ No. of Mice Inoculated . |
|---|---|
| HSV-B7.1 | 3/6 (P = .182) |
| HSVrantes | 4/6 (P = .455) |
| HSV-B7.1 and HSVrantes | 1/6 (P = .015) |
| HSVlac | 6/6 |
| HSV Amplicon . | No. of Mice With Tumor/ No. of Mice Inoculated . |
|---|---|
| HSV-B7.1 | 3/6 (P = .182) |
| HSVrantes | 4/6 (P = .455) |
| HSV-B7.1 and HSVrantes | 1/6 (P = .015) |
| HSVlac | 6/6 |
EL4 cells were infected in vitro with HSV amplicon virus at an estimated MOI of 1 and maintained in culture for 8 hours. Viable HSV amplicon-infected EL4 cells (106) were inoculated SC in mice and tumor presence was recorded at 1 month. Statistical analysis using Fisher’s exact test and the P value for each group compared with the control group (HSVlac) is shown in parentheses.