Table 1. Haplotype Segregating With the... | American Society of Hematology

Table 1.

Haplotype Segregating With theCGA(Arg)410TGA(Ter) Mutation in PROS1 of Affected Family Members

Marker	Distance (cM)^*	Frequency of Founder Allele^†	Families With the Arg 410Ter Mutation^‡
Marker	Distance (cM)^*	Frequency of Founder Allele^†	F	G	J	Fam-10
D3S3571			248	262	256
	4.4
D3S3545			84	84	82	88
	2.7
D3S1296		0.4000	180	180	180	178
	10.8
D3S3633		0.0200	133	133	133	123
	3.0
D3S1276		0.3700	194	194^1-153	194	196
	0.4
D3S1595		0.2679	305	305	305	297
	2.6
D3S3634		0.0200	243	243	243	251
	0.2
D3S3556		0.2300	166	166	166	174
	1.5
D3S1603		0.0536	175	175	175	173
	0.1
D3S3716		0.4600	233	233	233	235
	1.9
D3S1271			157	155	155	155
	3.0
D3S3574			102	108	108	110

Marker	Distance (cM)^*	Frequency of Founder Allele^†	Families With the Arg 410Ter Mutation^‡
Marker	Distance (cM)^*	Frequency of Founder Allele^†	F	G	J	Fam-10
D3S3571			248	262	256
	4.4
D3S3545			84	84	82	88
	2.7
D3S1296		0.4000	180	180	180	178
	10.8
D3S3633		0.0200	133	133	133	123
	3.0
D3S1276		0.3700	194	194^1-153	194	196
	0.4
D3S1595		0.2679	305	305	305	297
	2.6
D3S3634		0.0200	243	243	243	251
	0.2
D3S3556		0.2300	166	166	166	174
	1.5
D3S1603		0.0536	175	175	175	173
	0.1
D3S3716		0.4600	233	233	233	235
	1.9
D3S1271			157	155	155	155
	3.0
D3S3574			102	108	108	110

Sex average distance.

†

CEPH allele frequencies based on study of 56 chromosomes for the markers D3S1595 and D3S1603, 54 chromosomes for the markers D3S1296 and D3S1276, and 28 chromosomes for the markers D3S3633, D3S3634, D3S3556, and D3S3716.6 7

‡

Preserved founder alleles are within the dark shaded region.

F1-153

In family G, it could not be decided whether the mutation segregates with the 194-bp or 196-bp allele for the marker D3S1276.

View Large

This Feature Is Available To Subscribers Only