Pediatric Myelodysplastic and Myeloproliferative Disorders
| Myelodysplastic syndromes (French-American-British) |
| Refractory anemia |
| Refractory anemia with ring sideroblasts |
| Refractory anemia with excess blasts |
| Refractory anemia with excess blasts in transformation |
| Chronic myelomonocytic leukemia |
| Juvenile myelomonocytic leukemia (diagnostic criteria)* |
| Suggestive clinical |
| Hepatosplenomegaly |
| Lymphadenopathy |
| Pallor |
| Fever |
| Skin rash |
| Minimal laboratory (all 3 fulfilled) |
| No Philadelphia chromosome, no bcr/abl rearrangement |
| Peripheral blood monocyte count >1 × 109/L |
| Bone marrow blasts <20% |
| Criteria requested for definite diagnosis (at least 2) |
| Hemoglobin F increased for age |
| Myeloid precursors on peripheral blood smear |
| White blood count >10 × 109/L |
| Clonal abnormality (including monosomy 7) |
| GM-CSF hypersensitivity of myeloid progenitors in vitro |
| Myeloproliferative syndromes |
| Chronic myeloid leukemia |
| Polycythemia vera |
| Primary thrombocythemia |
| Myelofibrosis/agnogenic myeloid metaplasia |
| Transient myeloproliferative syndrome |
| Myelodysplastic syndromes (French-American-British) |
| Refractory anemia |
| Refractory anemia with ring sideroblasts |
| Refractory anemia with excess blasts |
| Refractory anemia with excess blasts in transformation |
| Chronic myelomonocytic leukemia |
| Juvenile myelomonocytic leukemia (diagnostic criteria)* |
| Suggestive clinical |
| Hepatosplenomegaly |
| Lymphadenopathy |
| Pallor |
| Fever |
| Skin rash |
| Minimal laboratory (all 3 fulfilled) |
| No Philadelphia chromosome, no bcr/abl rearrangement |
| Peripheral blood monocyte count >1 × 109/L |
| Bone marrow blasts <20% |
| Criteria requested for definite diagnosis (at least 2) |
| Hemoglobin F increased for age |
| Myeloid precursors on peripheral blood smear |
| White blood count >10 × 109/L |
| Clonal abnormality (including monosomy 7) |
| GM-CSF hypersensitivity of myeloid progenitors in vitro |
| Myeloproliferative syndromes |
| Chronic myeloid leukemia |
| Polycythemia vera |
| Primary thrombocythemia |
| Myelofibrosis/agnogenic myeloid metaplasia |
| Transient myeloproliferative syndrome |
Niemeyer et al.17