Measured Extent of T-Cell Depletion In Vitro and Numbers of T Cells Infused
| . | Ulm . | Royal Free . | Riyadh . | Study Group . | Historic Group . |
|---|---|---|---|---|---|
| No. of patients measured | 40 | 15 | 13 | 68 | 40 |
| Mononuclear cells (×108/kg) | 1.4 (0.5-4.0) | 0.5 (0.2-0.8) | 0.1 (0.1-2.4) | 1.0 (0.1-4.0) | 2.2 (0.1-6.0) |
| T cells (%) | 0.8 (0.0-3.0) | 0.2 (0.0-7.5) | 0.2 (0.0-2.7) | 0.4 (0.0-7.5) | 1.0 (0.0-10.0) |
| T cells infused (×106/kg) | 0.8 (0.0-5.4) | 0.12 (0.0-3.7) | 0.04 (0.0-2.2) | 0.2 (0.0-5.4) | 1.7 (0.0-25.0) |
| . | Ulm . | Royal Free . | Riyadh . | Study Group . | Historic Group . |
|---|---|---|---|---|---|
| No. of patients measured | 40 | 15 | 13 | 68 | 40 |
| Mononuclear cells (×108/kg) | 1.4 (0.5-4.0) | 0.5 (0.2-0.8) | 0.1 (0.1-2.4) | 1.0 (0.1-4.0) | 2.2 (0.1-6.0) |
| T cells (%) | 0.8 (0.0-3.0) | 0.2 (0.0-7.5) | 0.2 (0.0-2.7) | 0.4 (0.0-7.5) | 1.0 (0.0-10.0) |
| T cells infused (×106/kg) | 0.8 (0.0-5.4) | 0.12 (0.0-3.7) | 0.04 (0.0-2.2) | 0.2 (0.0-5.4) | 1.7 (0.0-25.0) |
Cell numbers are reported as medians, with the range in parentheses. There was a statistically significant difference between each study center in the total numbers of mononuclear cells (P < .005), but there was no significant difference between centers in the percentage of residual T cells or the total numbers of T cells infused. However, there was a significant difference between the study group and the historic control group with regard to each of these parameters (P = .024 for percentage of T cells and P < .001 for total T cells).