Correlation Between Genetic Haplotype and ADA Level in Families With Occurrence of DBA and Isolated High ADA Level
| . | Genetic Haplotype Within the Family . | ||
|---|---|---|---|
| Same as DBA Case . | Different From DBA Case . | Total . | |
| eADA | |||
| Increased* | 14 | 1 | 15 |
| Normal | 3 | 16 | 19 |
| Total | 17 | 17 | 34 |
| . | Genetic Haplotype Within the Family . | ||
|---|---|---|---|
| Same as DBA Case . | Different From DBA Case . | Total . | |
| eADA | |||
| Increased* | 14 | 1 | 15 |
| Normal | 3 | 16 | 19 |
| Total | 17 | 17 | 34 |
Index DBA case of each family is indicated with an arrow on pedigrees in Fig 2A through F. Statistical analysis performed through Yates corrected Chi-square test: P < .0001; odds ratio = 74.67; exact confidence limits of odds ratio, (5.87 − 3,342.87).7
Both isolated high eADA individuals and other DBA cases within the family with high eADA activity are considered increased eADA.