Evolution of Biological Parameters Throughout 32 Pregnancies Associated With Severe Thrombocytopenia (Platelet Count <70 × 109/L)
Patient No. . | Mothers . | NNT (+/−) . | ||||||
---|---|---|---|---|---|---|---|---|
Platelet Nadir × 109/L (during pregnancy) . | Platelet Count × 109/L (postdelivery) . | Platelet Life Span . | PAIgG (+/−) . | Antiplatelet Autoantibody (MAIPA test) . | Autoimmunity . | |||
PlateletAssociated . | Circulating . | |||||||
3a* | 59 | 100 | AITP | + | ND | Neg | Neg | − |
3b* | 35 | ND | − | ND | Neg | Neg | − | |
6a | 30 | 67 | AITP | − | ND | Neg | Neg | + |
6b | 53 | 130 | − | Neg | Neg | ACA | + | |
8 | 60 | 100 | ND | − | ND | Neg | Neg | − |
9 | 35 | 40 | AITP | + | ND | Neg | ACA | − |
10 | 58 | 201 | ND | − | ND | GP Ib-IX | ND | + |
12a | 42 | 157 | AITP | − | ND | GPIb-IX | Neg | − |
12b | 65 | 166 | − | ND | GPIb-IX | Neg | − | |
14 | 60 | 135 | ND | − | ND | Neg | Neg | − |
15 | 52 | 248 | AITP | − | ND | Neg | ND | + |
17 | 35 | 167 | AITP | − | ND | Neg | Neg | + |
22* | 64 | 68 | AITP | + | Neg | Neg | Neg | − |
23 | 50 | 50 | N | − | ND | Neg | ND | − |
25 | 35 | 237 | ND | + | Neg | Neg | Neg | − |
26 | 57 | 190 | HS | − | ND | GPIb-IX | Neg | − |
28a | 69 | 115 | N | ND | ND | ND | ND | − |
28b | 58 | 100 | − | ND | ND | ND | − | |
29 | 40 | 30 | AITP | + | ND | Neg | Neg | + |
31a | 30 | ND | ND | ND | ND | Neg | ND | − |
31b | 26 | 95 | − | ND | Neg | ACA | − | |
32 | 35 | ND | ND | + | ND | Neg | Neg | − |
37 | 35 | 110 | AITP | − | Neg | Neg | Neg | + |
38 | 51 | 174 | ND | − | ND | Neg | Neg | − |
40 | <50 | 180 | HS | − | ND | Neg | Neg | − |
41a | 30 | ND | AITP | + | Neg | Neg | Neg | + |
41b | 32 | 103 | + | Neg | Neg | Neg | + | |
42a | 50 | 162 | HS | − | ND | Neg | Neg | + |
44 | 60 | 160 | UN | − | Neg | Neg | Neg | − |
47 | 12 | 35 | ND | + | Neg | Neg | Neg | − |
48 | 63 | 203 | HS | − | Neg | Neg | Neg | − |
50 | 50 | 192 | AITP | − | GPIIb-IIIa | Neg | ACA | − |
Patient No. . | Mothers . | NNT (+/−) . | ||||||
---|---|---|---|---|---|---|---|---|
Platelet Nadir × 109/L (during pregnancy) . | Platelet Count × 109/L (postdelivery) . | Platelet Life Span . | PAIgG (+/−) . | Antiplatelet Autoantibody (MAIPA test) . | Autoimmunity . | |||
PlateletAssociated . | Circulating . | |||||||
3a* | 59 | 100 | AITP | + | ND | Neg | Neg | − |
3b* | 35 | ND | − | ND | Neg | Neg | − | |
6a | 30 | 67 | AITP | − | ND | Neg | Neg | + |
6b | 53 | 130 | − | Neg | Neg | ACA | + | |
8 | 60 | 100 | ND | − | ND | Neg | Neg | − |
9 | 35 | 40 | AITP | + | ND | Neg | ACA | − |
10 | 58 | 201 | ND | − | ND | GP Ib-IX | ND | + |
12a | 42 | 157 | AITP | − | ND | GPIb-IX | Neg | − |
12b | 65 | 166 | − | ND | GPIb-IX | Neg | − | |
14 | 60 | 135 | ND | − | ND | Neg | Neg | − |
15 | 52 | 248 | AITP | − | ND | Neg | ND | + |
17 | 35 | 167 | AITP | − | ND | Neg | Neg | + |
22* | 64 | 68 | AITP | + | Neg | Neg | Neg | − |
23 | 50 | 50 | N | − | ND | Neg | ND | − |
25 | 35 | 237 | ND | + | Neg | Neg | Neg | − |
26 | 57 | 190 | HS | − | ND | GPIb-IX | Neg | − |
28a | 69 | 115 | N | ND | ND | ND | ND | − |
28b | 58 | 100 | − | ND | ND | ND | − | |
29 | 40 | 30 | AITP | + | ND | Neg | Neg | + |
31a | 30 | ND | ND | ND | ND | Neg | ND | − |
31b | 26 | 95 | − | ND | Neg | ACA | − | |
32 | 35 | ND | ND | + | ND | Neg | Neg | − |
37 | 35 | 110 | AITP | − | Neg | Neg | Neg | + |
38 | 51 | 174 | ND | − | ND | Neg | Neg | − |
40 | <50 | 180 | HS | − | ND | Neg | Neg | − |
41a | 30 | ND | AITP | + | Neg | Neg | Neg | + |
41b | 32 | 103 | + | Neg | Neg | Neg | + | |
42a | 50 | 162 | HS | − | ND | Neg | Neg | + |
44 | 60 | 160 | UN | − | Neg | Neg | Neg | − |
47 | 12 | 35 | ND | + | Neg | Neg | Neg | − |
48 | 63 | 203 | HS | − | Neg | Neg | Neg | − |
50 | 50 | 192 | AITP | − | GPIIb-IIIa | Neg | ACA | − |
Abbreviations: a, first pregnancy; b, second pregnancy; NNT, neonatal thrombocytopenia; ND, not determined; AITP, AITP-like profile; HS, profile evocative of hypersplenism; N, normal profile; UN, unclassable profile; PAIgG, platelet-associated IgG; GP, glycoprotein; Neg, negative; ACA, anticardiolipin antibody.
Previously detected thrombocytopenia.