Clinical Data for the Patients Studied
| Patient . | Sex/Age (yr) . | Cytogenetics . | WBC ×109/L . | Hb g/dL . | Plat ×109/L . | Mono ×109/L . | BM %Bl . | Treatment . | Survival (mo) . |
|---|---|---|---|---|---|---|---|---|---|
| JMML | |||||||||
| AJ | M/3 | Normal | ND | ND | ND | ND | ND | ND | ND |
| NL | F/3 | Normal | 5 | 10 | 24 | ND | ND | BMT | 9+ |
| HA | M/2 | mono22 | 36 | 9 | 145 | 6 | 2 | None | 16+ |
| CF | M/3 | t(3;10) | 54 | ND | 7 | 3 | ND | HU | ND |
| PR | F/4 | ND | ND | ND | ND | ND | ND | ND | ND |
| MS | M/0.2 | Normal | 46 | 9 | 104 | 6 | 9 | BMT | 30+ |
| CB | M/0.2 | Normal | 86 | 8 | 46 | 4 | 1 | BMT | 11 |
| CMML | |||||||||
| G | M/76 | Normal | 67 | 8 | 78 | 7 | 1 | 5aza | 21 |
| CL | F/71 | Misc | 1 | 9 | 45 | 0.2 | 2 | Hycam | 9 |
| RS | M/71 | ND | 8 | 9 | 48 | 4 | 0 | Hycam | 22 |
| WS | M/70 | Misc | 99 | 8 | 57 | 50 | 2 | Topo/araC | 11 |
| AR | M/38 | Misc | 74 | 6 | 32 | 17 | 5 | Topo/araC | 1+ |
| JT | M/55 | Normal | 22 | 10 | 67 | 6 | 0.2 | Topo/araC | 4+ |
| CT | M/58 | Normal | 12 | 10 | 130 | 4 | 3 | None | 0+ |
| LS | F/73 | Normal | 43 | 10 | 580 | 14 | 16 | None | 0+ |
| RB | M/75 | Normal | 29 | 13 | 229 | 9 | 9 | None | 0+ |
| WB | M/65 | del 7,del19 | 49 | 10 | 71 | 14 | 4 | Interferon | 2 |
| FB | M/72 | ND | 36 | 11 | 130 | 14 | 21 | Etoposide | 1 |
| GN | M/ND | ND | 70 | ND | ND | 35 | 5 | None | 24+ |
| GW | M/78 | Normal | 85 | ND | 62 | 43 | 10 | HU | 24 |
| RM | M/56 | Normal | 33 | 14 | 25 | 7 | 1 | None | 24+ |
| EB | M/71 | Normal | 140 | 6.7 | 40 | 11 | 25 | HU | ND |
| KP | M/50 | Normal | 79 | 13 | 63 | 6 | 1 | HU, Spl | 24+ |
| SB | M/64 | Normal | 290 | 10 | 71 | 64 | 4 | HU | <1 |
| PP | M/61 | Normal | 52 | 11 | 23 | 28 | 17 | HU | 1 |
| DJ | M/30 | Normal | 73 | 12 | 43 | 64 | 22 | HU | 6 |
| ED | M/65 | Normal | 67 | 12 | 350 | 13 | 5 | HU | 18 |
| LP | F/79 | Normal | 65 | 11 | 98 | 22 | 29 | None | 12 |
| Patient . | Sex/Age (yr) . | Cytogenetics . | WBC ×109/L . | Hb g/dL . | Plat ×109/L . | Mono ×109/L . | BM %Bl . | Treatment . | Survival (mo) . |
|---|---|---|---|---|---|---|---|---|---|
| JMML | |||||||||
| AJ | M/3 | Normal | ND | ND | ND | ND | ND | ND | ND |
| NL | F/3 | Normal | 5 | 10 | 24 | ND | ND | BMT | 9+ |
| HA | M/2 | mono22 | 36 | 9 | 145 | 6 | 2 | None | 16+ |
| CF | M/3 | t(3;10) | 54 | ND | 7 | 3 | ND | HU | ND |
| PR | F/4 | ND | ND | ND | ND | ND | ND | ND | ND |
| MS | M/0.2 | Normal | 46 | 9 | 104 | 6 | 9 | BMT | 30+ |
| CB | M/0.2 | Normal | 86 | 8 | 46 | 4 | 1 | BMT | 11 |
| CMML | |||||||||
| G | M/76 | Normal | 67 | 8 | 78 | 7 | 1 | 5aza | 21 |
| CL | F/71 | Misc | 1 | 9 | 45 | 0.2 | 2 | Hycam | 9 |
| RS | M/71 | ND | 8 | 9 | 48 | 4 | 0 | Hycam | 22 |
| WS | M/70 | Misc | 99 | 8 | 57 | 50 | 2 | Topo/araC | 11 |
| AR | M/38 | Misc | 74 | 6 | 32 | 17 | 5 | Topo/araC | 1+ |
| JT | M/55 | Normal | 22 | 10 | 67 | 6 | 0.2 | Topo/araC | 4+ |
| CT | M/58 | Normal | 12 | 10 | 130 | 4 | 3 | None | 0+ |
| LS | F/73 | Normal | 43 | 10 | 580 | 14 | 16 | None | 0+ |
| RB | M/75 | Normal | 29 | 13 | 229 | 9 | 9 | None | 0+ |
| WB | M/65 | del 7,del19 | 49 | 10 | 71 | 14 | 4 | Interferon | 2 |
| FB | M/72 | ND | 36 | 11 | 130 | 14 | 21 | Etoposide | 1 |
| GN | M/ND | ND | 70 | ND | ND | 35 | 5 | None | 24+ |
| GW | M/78 | Normal | 85 | ND | 62 | 43 | 10 | HU | 24 |
| RM | M/56 | Normal | 33 | 14 | 25 | 7 | 1 | None | 24+ |
| EB | M/71 | Normal | 140 | 6.7 | 40 | 11 | 25 | HU | ND |
| KP | M/50 | Normal | 79 | 13 | 63 | 6 | 1 | HU, Spl | 24+ |
| SB | M/64 | Normal | 290 | 10 | 71 | 64 | 4 | HU | <1 |
| PP | M/61 | Normal | 52 | 11 | 23 | 28 | 17 | HU | 1 |
| DJ | M/30 | Normal | 73 | 12 | 43 | 64 | 22 | HU | 6 |
| ED | M/65 | Normal | 67 | 12 | 350 | 13 | 5 | HU | 18 |
| LP | F/79 | Normal | 65 | 11 | 98 | 22 | 29 | None | 12 |
Abbreviations: Bl, blasts; Spl, splenectomy; HU, hydroxyurea; ND, not determined; Misc, miscellaneous chromosomal defects; 5aza, 5-azacytidine; Hycam, hycamp-tamine; topo/araC, topotecan plus cytosine arabinoside; NL is patient 36 and HA is patient 38 of The Hospital for Sick Children; CF is patient J96 and PR is patient J95 from UAB.